早期负性经历和DNA 甲基化对男性性取向的影响

男性性取向成因复杂，至今尚未明确。近年来，男性性取向成因的生物学研究不断取得新的成果，而环 境因素的影响却很少被关注。早期负性经历作为个体发育早期的一种特殊环境，可通过修饰基因DNA甲基化位点， 影响个体表型特征。鉴于男性性取向与早期负性经历和DNA甲基化之间的关系，并结合现有理论知识，本文从环境 和表观遗传学角度入手，提出“早期负性经历-DNA甲基化-男性性取向”假设，以期为后续研究提供线索。

Effect of adverse childhood experiences and DNA methylation on male sexual orientation

The causes for male sexual orientation are complicated, which have not yet been clarified. Recent years have witnessed fruitful progress in the field of biology, while the impact of environment has received little attention. Adverse childhood experiences (ACEs), identified as a special environment in the early stage of development, can affect the individual phenotype by DNA methylation. Given the relationships among male sexual orientation, ACEs, and DNA methylation, as well as based on the existing theory, this article proposes the model “ACEs-DNA methylation-male sexual orientation” from the perspective of environment and epigenetics, aiming to provide a theoretical basis for future research.