C反应蛋白与慢性自发性荨麻疹患者临床特征的关系

目的：探讨慢性自发性荨麻疹患者外周血C反应蛋白(C reactive protein，CRP)水平与疾病严重程度及第 二代抗组胺药物治疗效果的关系。方法：对2013年8月至2015年3月在中南大学湘雅医院皮肤科就诊的605例慢性自 发性荨麻疹患者的临床资料进行回顾性分析。根据患者疾病严重程度评分下降是否小于50%将患者分为无效组和有 效组，利用t检验及Pearson相关分析对患者的疾病严重程度、第二代抗组胺药疗效等临床特征资料与CRP的关系进 行分析。结果：在中重度慢性自发性荨麻疹患者中，不同严重程度的患者其CRP水平存在差异(t=–2.715，P<0.01)； 同时，第二代抗组胺药物治疗有效组与无效组患者时，有效组治疗前CRP水平低于无效组分别为(2.5764±2.5059)和 (3.6715±4.7732) mg/dL]，差异有统计学意义(t=–2.187，P<0.05)。结论：慢性自发性荨麻疹患者治疗前CRP水平可能与 疾病严重程度有关，并且在不同疗效的患者间存在差异。

Association between C reactive protein and clinical#br# characteristics in patients with chronic spontaneous urticaria

Objective: To explore the association among C reactive protein (CRP) level, disease severity and non-sedating antihistamine drug effi cacy in patients with chronic spontaneous urticaria. Methods: A total of 605 patients with chronic spontaneous urticaria from August 2013 to March 2015, diagnosed by dermatologist of Xiangya Hospital according to the guideline, were enrolled in present study. The patients were divided into two groups according to the weekly urticaria activity score (UAS): a response group (more than 50% reduction) and a nonresponse group (less than 50% reduction). T test and Pearson correlation analysis were used to analyze the correlation between the clinical characteristics (such as disease severity, drug efficacy) and CRP in patientswith chronic spontaneous urticaria. Results: The CRP levels were significantly higher in patients with severe chronic spontaneous urticaria as compared to those with moderate chronic spontaneous urticaria (t=–2.715, P<0.01). Meanwhile, after treatment with secondary antihistamine drug, the patients with lower CRP levels showed better responses than those with higher CRP levels (2.5764±2.5059) and (3.6715±4.7732) mg/dL respectively; t=–2.187, P<0.05]. Conclusion: Serum CRP level before the treatment may be correlated with the severity of chronic spontaneous urticaria and efficacy of treatment.