右冠状动脉缺血预处理对兔心肌缺血再灌注损伤的保护作用

目的：探索右冠状动脉缺血预处理、后处理对兔的心肌缺血再灌注损伤的保护作用。方法：将30只新西兰大白兔随机分为对照组(n=7)、缺血再灌注损伤组(n=8)、右冠状动脉缺血预处理组(n=8)、右冠状动脉缺血后处理组(n=7)，分别抽取术前、术后1及6 h的静脉血，测肌酸激酶同工酶、肌钙蛋白T，计算心肌梗死面积。结果：与缺血再灌注损伤组比较，右冠状动脉缺血预处理组、右冠状动脉缺血后处理组肌酸激酶同工酶、肌钙蛋白T浓度在术后1和6 h明显降低，差异均有统计学意义(均P<0.05)；心肌梗死面积明显缩小，差异均有统计学意义(均P<0.05)。结论：在新西兰大白兔的心肌缺血再灌注心肌梗死模型中，右冠状动脉缺血预处理、右冠状动脉缺血后处理对心肌缺血再灌注损伤有明显的保护作用。

Protective effect of right coronary artery ischemic preconditioning on myocardial ischemia reperfusion injury #br# in rabbit heart

Objective: To explore the protective effects of right coronary artery ischemic preconditioning and post-conditioning on myocardial ischemia reperfusion injury in rabbit heart. Methods: A total of 30 rabbits were randomly divided into 4 groups: a control group (n=7), an ischemia reperfusion group (IR group, n=8), an ischemic preconditioning group (IPC group, n=8) and an ischemic post-conditioning group (IPO group, n=7). Venous blood samples were taken at pre-operation, 1 and 6 h post-operation, and the concentration of serum creatine kinase isoenzyme (CK-MB) and cardiac troponin-T (cTn-T) were measured. The infarct area of cardiac muscle was calculated. Results: Compared with the IR group, the levels of CK-MB and cTn-T at 1 and 6 h post-operation in the IPC group and the IPO group were reduced (all P<0.05). Compared with the IR group, the infarct size in the IPC group and the IPO group was significantly decreased, with significant difference (both P<0.05) . Conclusion: Right coronary artery ischemic preconditioning and post-conditioning exert significant protective effects on the myocardial ischemia reperfusion injury in New Zealand rabbits.