马来酸噻吗洛尔滴眼液治疗浅表型婴幼儿血管瘤用药方法的探讨

目的：探讨使用马来酸噻吗洛尔滴眼液治疗婴幼儿血管瘤的最佳用法与用量。方法：将250例浅表型婴幼 儿血管瘤患者均分为5组；即外敷组和每日外涂2，4，6，8次组。观察不同用药方式(外敷及外涂)及不同用药频率对 疗效的影响。结果：外敷马来酸噻吗洛尔滴眼液2次/d，每次30 min组的疗效优于外涂组2 次/d(P<0.001)，外涂2 次/d 或4 次/d的疗效与外涂6 次/d比较，差异有统计学意义(P<0.001)，外涂6次/d的疗效与外涂8 次/d或外敷2 次/d之间比 较，差异无统计学意义(P>0.05)。结论：马来酸噻吗洛尔滴眼液治疗婴幼儿血管瘤的疗效与用药量相关，6次/d外涂 能达到最佳的疗效。

Usage and efficacy of timolol maleate eye drops in treatment of superficial infantile hemangioma

Objective: To determine drug dose and usage of timolol maleate eye drops in the treatment of superfi cial infantile hemangioma. Methods: A total of 250 superfi cial hemangioma infants were recruited and assigned into 5 groups (n=50 for each group): an external application group and 4 exterior coating groups (2, 4, 6, 8 times per day). We evaluated the therapeutic eff ect of diff erent methods for drug application (external application or exterior coating) and the frequency for drug administration on superfi cial infantile hemangioma. Results: Th e external application group (twice a day and 0.5 hour per time) showed bett er eff ect than that in the exterior coating group with twice a day (P<0.001). Th e diff erence in therapeutic eff ect between the exterior coating group with 6 times a day and exterior coating group with twice a day or with 3 times a day was signifi cant (P<0.001). Th e diff erences in drug effi cacy were not found among the exterior coating group with 6 times a day, the exterior coating group with 8 times a day, or the external application group with twice a day (All P>0.05). Conclusion: Drug dose may affect the therapeutic effect of timolol maleate eye drops in superficial hemangioma infants, and exterior coating with 6 times a day may achieve the best curative effect.