未致敏小鼠实验性日本血吸虫虫卵肉芽肿中淋巴细胞的动态观察

将日本血吸虫虫卵经尾静脉注入正常小鼠,观察沉积在肺血管床形成的虫卵肉芽肿内淋巴细胞的动态变化。结果表明,注卵后第一天即见淋巴细胞浸润,随后,淋巴细胞均数及其所占反应细胞总数的构成比逐渐增加。酯酶染色结果表明,注卵后10天内酯酶染色阳性细胞高于阴性细胞数,第10天后发生逆转;至第35天时更为明显。

KINETIC OBSERVATION OF LYMPHOCYTIC POPULATIONS IN EXPERIMENTAL S. JAPONICA EGG GRANULOMAS

This paper reports kinetic observations on the population of lymphocytes in the S. japonica egg granulomas induced by injection eggs through the tail vein and then precipated within the pulmonary vasculature of previously not sensitized mice.Twenty four hours after the egg injection, lymphocytes occurred in the granulomas and accounted for 9.85% of the inflammatory cells. The total lymph-ocytic counts began to increase from the 4th day and sustained stable relation until the 22nd day. Thereafter the total lymphocytic counts and constituent ratios both increased rather evidently.With regard to ANAE positive and negative cells, within 7 days after egg injection, positive cells are significantly higher than negative cells; after the 10th day, this condition reversed. As ANAE positive cells are mostly T cells and the negative cells are B cells. It might be suggest that: 1, In the initial stage of S. japonica egg granuloma formation, T cells play an important role, this may be similar with S. mansoni egg granuloma, and 2, B cells may play an important role during the course of immune modulation of the egg granuloma reaction. The latter is different from S. mansoni egg granuloma and may be responsible for the difference in the mechanism of egg granuloma formation and modulation between the two species of the parasites.