首页 | 本学科首页   官方微博 | 高级检索  
检索        

超声心动图评价心力衰竭大鼠模型心功能改变
引用本文:朱文晖,张晓红,肖渊茗.超声心动图评价心力衰竭大鼠模型心功能改变[J].中南大学学报(医学版),2009,34(5):453-456.
作者姓名:朱文晖  张晓红  肖渊茗
作者单位:1.中南大学湘雅三医院超声科, 长沙 410013; 2.郴州市第一人民医院超声科, 湖南 郴州 423000
摘    要:目的:用超声心动图检测大鼠心力衰竭模型心功能改变,并探索模型大鼠心功能与血清B型钠尿肽(B-type natriuretic peptide,BNP)的关系。方法:选用体质量200~220 g的2月龄雄性SD大鼠120只,随机分为3组。手术组(80只):麻醉后行开胸术,打开心包,结扎左冠状动脉前降支。假手术组(20只):同样开胸,打开心包,但不结扎。正常组(20只):不予任何处理。术后每日观察大鼠的精神状态、术前1天及术后第6周末测定大鼠的体质量等一般情况的变化。术前及术后第6周末均行超声心动图检查,以评价实验大鼠的心功能改变,并取术后大鼠血清行BNP水平检测。结果:术后存活的手术组大鼠于术后第10天左右出现明显心力衰竭体征。手术组与正常组及假手术组比较:左室内径指数(LV指数)增大,左室后壁指数(LVPW指数)及室间隔厚度指数(IVS指数)减小,左室内径缩短率(FS)及射血分数(EF)均下降,其差异具有统计学意义(P<0.05)。左房内径指数(LA指数)变化无明显差异(P>0.05);BNP水平明显升高,其升高程度与EF,FS呈负相关(分别r=-0.927,r=-0.894,P<0.05);与LV指数呈正相关(r=0.409,P<0.05)。结论:结扎大鼠的左冠状动脉前降支能成功制备大鼠心力衰竭模型。超声心动图能很好地评价心衰大鼠的心功能改变。

关 键 词:心力衰竭  心功能  超声心动图描记术  血清B型钠尿肽  大鼠  
收稿时间:2008-7-21

Evaluation of heart function in heart failure rat model by echocardiography
ZHU Wenhui,ZHANG Xiaohong,XIAO Yuanming.Evaluation of heart function in heart failure rat model by echocardiography[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2009,34(5):453-456.
Authors:ZHU Wenhui  ZHANG Xiaohong  XIAO Yuanming
Institution:1.Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha 410013;
2.Department of Ultrasound, First Chenzhou Hospital, Chenzhou Hunan 423000, China
Abstract:ObjectiveTo detect variation in cardiac function in heart failure rat model by echocardiography, and to explore the relationship between cardiac function and blood serum B-type natriuretic peptide (BNP).MethodsA total of 120 two-month-old male SD rats (body mass 200~220 g) were randomly assigned to 3 groups: an operation group (80 rats) had thoracotomy, with open pericardium and ligature of the anterior descending branch of the left coronary artery; a sham operation group (20 rats) had thoracotomy and open pericardium but no ligature of the artery; and a normal group (20 rats) had no treatment. We observed the general state of the rats every day after the operation, and we measured the rats’ body mass the day before the operation and at the end of 6th week after the operation. To evaluate the change of heart function in heart failure rats, echocardiography was used to detect the level of BNP after the operation.ResultsThe operation group that survived showed obvious objective sign of heart failure about 10 days after the surgery. Compared with the normal group and the sham operation group, left ventricle index in the operation group got higher, left ventricle posterior wall index and interventricular septum index got lower, fraction shortening and ejection fraction got lower(P<0.05). There was no difference in the left atrium index (P>0.05). The BNP level was significantly increased (P<0.05), which was inversely related to ejection fraction and fraction shortening (r=-0.927,r=-0.894,P<0.05, respectively). The BNP level also had a positive relationship with the left ventricle index(r=0.409,P<0.05).ConclusionLigature of the anterior descending branch of the left coronary artery in rats can successfully create heart failure model. Echocardiography can well evaluate the heart function in heart failure rat models.
Keywords:heart failure  heart function  echocardiography  blood serum B-type natriuretic peptide  rat
本文献已被 维普 万方数据 等数据库收录!
点击此处可从《中南大学学报(医学版)》浏览原始摘要信息
点击此处可从《中南大学学报(医学版)》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号