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子宫颈癌新辅助化疗的疗效
引用本文:曹兰琴,黎欣,李新国,张怡.子宫颈癌新辅助化疗的疗效[J].中南大学学报(医学版),2009,34(6):527-530.
作者姓名:曹兰琴  黎欣  李新国  张怡
作者单位:中南大学湘雅医院妇产科, 长沙 410008
基金项目:湖南省科技计划项目,Science and Technology Development Program of Hunan
摘    要:目的:研究宫颈癌新辅助化疗的疗效及与临床资料之间的关系。方法:选择行新辅助化疗的Ib2~IIIa期宫颈癌患者97例,分析化疗后的近期疗效,影响疗效的有关因素和术后病理结果。结果:新辅助化疗的近期有效率为86.6%;与疗效有关的因素为临床分期和病理类型;新辅助化疗后84例患者可以手术,术后病理降级的有17例,术后淋巴结阳性者19例,宫旁浸润者6例;随访中1例患者术后1年内死亡,5例复发,余患者均健在。结论:局部晚期宫颈癌新辅助化疗效果好,新辅助化疗后手术能改善患者预后,提高术后生存率。

关 键 词:宫颈癌  新辅助化疗  子宫切除术  
收稿时间:2009-1-14

Effect of neoadjuvant chemotherapy on cervical carcinoma
CAO Lanqin,LI Xin,LI Xinguo,ZHANG Yi.Effect of neoadjuvant chemotherapy on cervical carcinoma[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2009,34(6):527-530.
Authors:CAO Lanqin  LI Xin  LI Xinguo  ZHANG Yi
Institution:Department of Gynecology and Obstetrics, Xiangya Hospital, Central South University, Changsha 410008, China
Abstract:ObjectiveTo investigate the effect of neoadjuvant chemotherapy on cervical carcinoma and its association with clinical data.MethodsA total of 97 patients with stage Ib2~IIIa of cervical cancinoma were treated with neoadjuvant chemotherapy. The effect of chemotherapy, factors associated with outcome of chemotherapy, and histology were analyzed.ResultsEffective rate of chemotherapy was 86.6% which was associated with clinical stage and histology. Eight-four patients received radical hysterectomy. The histological grade of 17 patients was lowered, lymph nodes in 19 patients were positive, and 6 patients had parametrium invasion. One patient died within 1 year after the operation, and 5 patients recurred. ConclusionThe effect of neoadjuvant chemotherapy for locally advanced cervical cancinoma is good. Surgery after chemotherapy can improve the prognosis and 5-year survival rate.
Keywords:cervical carcinoma  neoadjuvant chemotherapy  hysterectomy
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