寻常型银屑病患者血清中抗真菌抗原IgG,IgA,IgM水平初探

目的 :检测寻常型银屑病 (PV)患者血清中糠秕马拉色菌和白色念珠菌抗原特异性抗体水平 ,探讨两种真菌与寻常型银屑病发病的关系。方法 :间接ELISA法测定PV患者和健康对照组血清中抗糠秕马拉色菌整菌抗原 (马Wag)和可溶性抗原 (马Sag)及白色念珠菌整菌抗原 (白Wag)和可溶性抗原 (白Sag)IgG ,IgA ,IgM水平。结果 :PV患者抗马WagIgG水平较健康对照组明显增高 (P <0 .0 1) ;抗白WagIgG水平亦较健康对照组明显增高 (P<0 .0 5 )。PV患者抗马SagIgM ,抗白WagIgM ,抗白SagIgA水平明显低于健康对照组 (P <0 .0 5 )。结论 :PV患者存在体液免疫异常 ;糠秕马拉色菌和白色念珠菌可能与寻常型银屑病发病有关。

Serum levels of antibodies for IgG, IgA, and IgM against the fungi antigen in psoriasis vulgaris

Objective To detect the serum levels of antibodies against Malassezia furfur and Candida albicans in patients with psoriasis vulgaris (PV), and to investigate the relationship between Malassezia furfur or Candida albicans and pathogenesis of PV.Methods The serum levels of antibodies for IgG, IgA, and IgM against the whole cell antigen Wag and soluble antigen (Sag) of Malassezia furfur and Candida albicans in 40 PV patients and 20 healthy controls were detected by indirect-ELISA.Results The serum levels of IgG against Wag of Malassezia furfur and Candida albicans were significantly higher in PV patients than those in the healthy controls (P<0.01,P<0.05,respectively). The serum levels of IgM against Sag of Malassezia furfur and Candida albican, IgA against Sag of Candida albicans were significantly lower in PV patients than those in the healthy controls (P<0.05).Conclusion There are some humoral immunity abnormalties in PV patients. Malassezia furfur and Candida albicans may be related to the pathogenesis of PV.