儿童龋病与唾液CCL28 和sIgA 抗体的相关性

目的：探讨儿童唾液中趋化性细胞因子CCL28含量和sIgA 抗体分泌与儿童患龋状况之间的联系。方法： 抽取长沙市两所幼儿园3~5岁108名幼儿进行龋齿检查，根据检查结果分为无龋组龋失补指数(dynamical mean-field theory，DMFT)=0]；低龋组(DMFT=1~4)；高龋组(DMFT≥5)，收集非刺激性全唾液样本，用酶联免疫吸附试验 (ELISA) 定量检测唾液中 CCL28及sIgA的含量，并对结果进行统计学分析。结果：108名儿童唾液中CCL28的浓度为 (121.22±32.63) pg/mL，sIgA 的浓度为(16.49±8.02) μg/mL，两者之间存在线性正相关关系(r=0.734)，且儿童唾液样本中 CCL28和sIgA含量随儿童患龋程度而增加(P<0.05)。结论：儿童龋患能够促进CCL28和sIgA分泌，且CCL28和sIgA的分 泌量与龋患程度呈正相关；CCL28对唾液中sIgA 的分泌起促进作用。

Correlation between children's dental decay and the contents of saliva CCL28 and secretory immunoglobulin A

Objective: To explore the association of the dental decay of children with the contents of chemokine CCL28 and secretory immunoglobulin A (sIgA) in saliva. Methods: A total of 108 children in 2 kindergartens of Changsha, with age from 3 to 5 years old, were enrolled for this study. The saliva was collected from these children when they were in the examination of mouth. Th e children were divided into 3 groups: A non-caries group dynamical mean-field theory (DMFT)=0], a low caries group (DMFT=1–4) and a high caries group (DMFT≥5). Th e contents of CCL28 and sIgA were measured by ELISA. Results: The contents of CCL28 and sIgA in saliva were (121.22±32.63) pg/mL and (16.49± 8.02) μg/mL, respectively. A positive linear correlation was found between the CCL28 content and sIgA content in saliva (r=0.734). Th e CCL28 and sIgA contents in saliva were positively correlated with the degree of dental caries in children (P<0.05). Conclusion: The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva.