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代谢综合征与动脉粥样硬化的关系
作者姓名:Liu F  Zhang HY  Liu XN  Yang HY  Kang ZH  Shi XZ  Yang Y  Hui RT
作者单位:1. 100037,北京,中国医学科学院心血管病研究所,阜外医院心血管病超声科
2. 100037,北京,中国医学科学院心血管病研究所,阜外医院分子医学中心
3. 100037,北京,中国医学科学院心血管病研究所,阜外医院中德试验室
4. 青岛港口医院
基金项目:九七三国家重点基础研究发展规划课题基金资助项目 (G2 0 0 0 0 5 690 1)
摘    要:目的 探讨代谢综合征与动脉粥样硬化的关系。方法 将青岛港健康研究人群中 5 5~74岁的男性共 35 8名 ,分为代谢综合征患病组与非患病组 ,应用血管超声技术检测了该组人群颈动脉内膜 -中膜厚度、斑块性质、分级及斑块总积分 ,并对内膜 中膜厚度 (IMT)与代谢综合征各项诊断标准进行了相关分析。结果 代谢综合征患病组颈动脉IMT值 (0 90mm± 0 12mm)、斑块总积分(3 5 8mm± 0 4 4mm)、斑块发生率 (6 4 2 % )及心血管病患病率 (47 5 % )均显著高于非患病组 (分别为 0 84mm± 0 11mm、2 4 5mm± 0 2 5mm、4 7 5 %及 12 2 % ,P均 <0 0 5 )。颈动脉IMT与收缩压、舒张压、血糖及腰围呈显著正相关 (r分别为 0 2 7、0 17、0 17及 0 12 ,P均 <0 0 5 )。结论 代谢综合征可以加速动脉粥样硬化的发生发展。对代谢综合征患者及早进行颈动脉的超声检查 ,将有助于心血管病事件的一级预防。

关 键 词:代谢综合征  动脉粥样硬化  血管超声技术  检测  诊断标准
修稿时间:2002年12月31

The association between metabolic syndrome and atherosclerosis
Liu F,Zhang HY,Liu XN,Yang HY,Kang ZH,Shi XZ,Yang Y,Hui RT.The association between metabolic syndrome and atherosclerosis[J].National Medical Journal of China,2003,83(15):1317-1320.
Authors:Liu Fang  Zhang Hong-ye  Liu Xiao-ning  Yang Huan-yi  Kang Zhao-hui  Shi Xiu-zhong  Yang Ying  Hui Ru-tai
Institution:Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China.
Abstract:OBJECTIVE: To explore the association between metabolic syndrome and atherosclerosis. METHODS: Carotid intima-media thickness (IMT) was detected and the atherosclerotic plaque was classified, graded, and scored in 358 retired males, aged 55 approximately 74, including 95 (26.6%) with metabolic syndrome (metabolic syndrome group) and 263 (73.5%) without metabolic syndrome (non-metabolic syndrome group). The correlation of IMT with every characteristic of metabolic syndrome diagnostic criteria was studied. RESULTS: The metabolic syndrome group had higher carotid IMT (0.90 mm +/- 0.12 mm versus 0.84 mm +/- 0.11 mm, P < 0.05), plaque score (3.58 mm +/- 0.44 mm vs 2.45 mm +/- 0.25 mm, P < 0.05), plaque occurrence rate (64.2% vs 47.5%, P < 0.05) and cardiovascular event morbidity (20.0% versus 12.2%, P < 0.05) compared with the non-metabolic syndrome group. IMT was significantly but weakly positively correlated with systolic blood pressure, diastolic blood pressure, glucose, and waistline (r = 0.27, r = 0.17, r = 0.17 and r = 0.12 respectively, all P < 0.05). CONCLUSION: Metabolic syndrome accelerates the course of atherosclerosis. Detecting carotid artery as early as possible by vascular ultrasound is helpful to primary prevention of cardiovascular events in the patients with metabolic syndrome.
Keywords:Ultraso nography  doppler  Carotid artery  Atherosclerosis  Metabolic syndrome
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