| 东莨菪碱对大鼠血清和尿吗啡浓度的影响 |
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| 引用本文： | 周文华,朱波,陈琦君,张富强,杨国栋.东莨菪碱对大鼠血清和尿吗啡浓度的影响[J].中华医学杂志,1995(1). |
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| 作者姓名： | 周文华 朱波 陈琦君 张富强 杨国栋 |
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| 作者单位： | 宁波市微循环与莨菪类药研究所 |
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| 摘 要： | 实验应用放射免疫法测定大鼠血清和尿吗啡浓度。东莨菪碱明显增加成瘾大鼠吗啡的排泄（ｎ＝８），并且与东莨菪碱注射剂量呈正相关。东莨菪碱明显增加末次注射吗啡２小时后大鼠血清结合吗啡浓度（ｎ＝６，Ｐ＜０．０５），２４小时后其血清游离吗啡和结合吗啡浓度较对照组升高（ｎ＝６，Ｐ＜０．０５）。预先腹腔内注射东莨菪碱（０．５ｍｇ／ｋｇ）３天后，再皮下注射吗啡（１０ｍｇ／ｋｇ），大鼠血清游离吗啡浓度明显升高（ｎ＝６，Ｐ＜０．０５）。结果表明，东莨菪碱可刺激吗啡代谢和促进吗啡皮下吸收入血液，从而增加、增快吗啡的排泄。
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| 关 键 词： | 吗啡瘾，东莨菪碱，代谢解毒，药物 |
Effect of scopolamine on morphine levels in serum andurine in rats |
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| Zhou Wenhua , Zhu Bo,
Chen Qijun,et al..Effect of scopolamine on morphine levels in serum andurine in rats[J].National Medical Journal of China,1995(1). |
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| Authors: | Zhou Wenhua Zhu Bo Chen Qijun |
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| Institution: | Zhou Wenhua , Zhu Bo,
Chen Qijun, et al. |
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| Abstract: | ree
morphine and conjugated morphine were de-termined by radioimmunoassay. Excretion of
conlugatedmorphines in urine was increased significantly by treat-ment with scoplamine in a
dose-related manner in mor-phine-dependent Sprague-Dawley rats (n= 8 ). Conju-gated
morphine in serum was increased by administra-tion of scopolamine greater than that of
controls at 2h,and both free and conjugated morphine in serum wereenhanced at 24h after last
injection of morphine in mor-phine-dependent rats (n = 6). After use of scopolamine( 0. 5mg/kg,
bid, ip) for 3d the rats (n = 6) received sin-gle inJection of morphine (10mg/kg, sci) , the levels
offree morphine were increased greater than those of con-trols at 2 and 10h. The data showed
that scopolaminemay not only induced the metabolism of morphine in liv-er, but also fascilitated
subcutaneous absorption of mor-phine, which result in enhancing the excretion of mor-phine. |
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| Keywords: | Scopolamine Morphine Conju-gated morphine |
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