北京地区幽门螺杆菌耐药情况及其变化趋势

目的 了解北京地区幽门螺杆菌（Hp）对甲硝唑、克拉霉素及阿莫西林的耐药情况及其变化趋势。方法 从来自胃镜室的159例有上胃肠道症状的患者取得胃窦黏膜组织，经微需氧条件培养获得临床分离的Hp菌株，采用E-试验的方法测定Hp对甲硝唑、克拉霉素及阿莫西林的最低抑菌浓度（MIC）。结果 北京地区Hp对甲硝唑和克拉霉素的耐药率分别为：1999-2000年36．0％（18／50）和10．0％（5／50），2001-2002年43．1％（47／109）和18．3％（20／109），甲硝唑和克拉霉素的混合耐药率为：1999-2000年10．0％（5／50），2001-2002年14．7％（16／109），仅发现1株阿莫西林耐药菌株（1／49）。结论 北京地区Hp对甲硝唑的耐药率较高且呈逐年上升的趋势，对克拉霉素的耐药菌株及混合耐药菌株也较为常见，阿莫西林耐药菌株罕见。

The epidemiology of Helicobacter pylori resistance to antibiotics in Beijing

Objective To investigate the prevalence of Helicobacter pylori(H. pylori) resistance to metronidazole, clarithromycin and amoxicillin in Beijing. Methods H. pylori strains were cultured from the gastric biopsiy samples obtained from 159 patients with upper abdominal symptoms by gastroendoscopy. Minimal inhibitory concentrations of antibiotics were determined by E-test method. Results The resistance rates of H. pylori to metronidazole and clarithromycin in Beijing were 36.0%(18/50)and 10.0%(5/50)in 1999- 2000, 43.1%(47/109)and 18.3%(20/109)in 2001-2002,respectively. H.pylori resistance to both metronidazole and clarithromycin were 10.0% (5/50)in 1999-2000 and 14.7% (16/109)in 2001-2002. Only one strain was found resistant to amoxicillin in 49 patients. Conclusion The resistance rates of H. pylori to metronidazole and clarithromycin were increased in Beijing in recent years. The strains resistant to amoxicillin were rare.