早期梅毒患者脑血流灌注显像研究

目的 了解早期梅毒患者的脑血流灌注情况。方法病例组为32例早期梅毒患者，对照组为15名健康人，对两组对象行^99mTc-双半胱乙酯脑血流灌注显像，并作图像视觉分析。结果病例组32例均有弥漫性、斑片样脑血流低灌注，14例患者在多个局部表现得更为明显，共46例次。其中累及左额叶6例次，右额叶3例次，左顶叶7例次，右顶叶6例次，左颞叶11例次，右颞叶5例次，左枕叶3例次，左基底节3例次，小脑和脑内核团各1例次。对照组无一人异常。结论早期梅毒患者均已存在脑血流异常，单光子发射计算机断层图像普遍显示弥漫性、斑片样低灌注。

Cerebral blood flow perfusion imaging by single photon emission computed tomography in patients with early syphilis

Objective To study the cerebral blood flow perfusion imaging by single photon emission computed tomography (SPECT) in patients with early syphilis. Methods SPECT was performed with 99m Tc ECD as imaging agent on 32 patients with early syphilis and 15 healthy controls. Visual analysis was made. Results Disseminated patchy radioactive rarefection mainly in cerebral cortex, suggesting hypoperfusion of regional cerebral blood flow, was shown in all patients. In particular 14 patients displayed multi regional obvious hypoperfusion patches: 6 in left frontal lobe, 3 in right frontal lobe, 7 in left parietasl lobe, 6 in right parietal lobe, 11 in left temporal lobe, 5 in right temporal lobe, 3 in left occipital lobe, 3 in left basal ganglia, 1 in cerebellum, and 1 in intrecerebral nucleus. No abnormality was found in the controls. Conclusion Cerebral blood flow abnormality exists in patient with early syphilis manifesting as patchy hypoperfusion in SPECT imaging.