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新的氧输送渠道在防治烧伤休克及减轻缺氧性损伤中的临床应用
作者姓名:Sun YH  Zhang PZ  Hu XH  Chen Z  Cheng AY  Zhong SH
作者单位:1. 100035,北京积水潭医院烧伤科
2. 广州红十字会医院烧伤科
基金项目:国家重点基础研究发展规划基金资助项目(G19990 5 42 0 2 ),北京市优秀人才培养专项经费资助项目 (D类,2 0 0 2年 )
摘    要:目的 探讨高氧复方氯化钠溶液 (HCSCS)对烧伤休克的防治作用和预后。方法  (1 )选择 2 0 0 1年 1月~ 2 0 0 3年 1月北京积水潭医院烧伤科收治的烧伤面积 5 0 %~ 6 9%的烧伤病人 ,随机分为 2组 ,分别是治疗组补充高氧复方氯化钠溶液、对照组补充复方氯化钠溶液 ,观察休克期度过平稳与否、经皮氧分压、血红蛋白 (Hb)、血球压积 (Hct)以及其并发症等 ,判断高氧液的疗效。 (2 )选择 2 0 0 2年~ 2 0 0 3年烧伤面积 >70 %病人 1 6例观察其氧分压 (PaO2 )、并发症、血色素 (Hb)、血球压积(Hct)、血乳酸 (Lactate)以及总补液量和尿量。结果 临床观察中 ,(1 )治疗组较对照组休克期度过平稳、并发症少 ,4 8h输液总量少 ,血氧分压和经皮氧分压明显高于对照组 ,血氧饱和度无差异性。 (2 )烧伤面积 >70 %病人血氧分压维持水平较高 ,血乳酸基本在正常范围内 ,仅 2例出现并发症 ,1例死亡。结论 早期应用高氧复方氯化钠溶液对防治烧伤休克和预后有良好疗效

关 键 词:氧输送渠道  烧伤  休克  缺氧性损伤  预后  血氧分压

A new method of oxygen delivery to preventing and relieving the anoxia injury--an experimental study and clinical application of hyperoxygen compound sodium chloride solution in treatment of burn shock
Sun YH,Zhang PZ,Hu XH,Chen Z,Cheng AY,Zhong SH.A new method of oxygen delivery to preventing and relieving the anoxia injury--an experimental study and clinical application of hyperoxygen compound sodium chloride solution in treatment of burn shock[J].National Medical Journal of China,2004,84(1):18-21.
Authors:Sun Yong-hua  Zhang Pu-zhu  Hu Xiao-hua  Chen Zhong  Cheng An-yuan  Zhong Sui-hang
Institution:Department of burns, Beijing Jishuitan Hospital, Beijing 100035, China.
Abstract:OBJECTIVE: To evaluate the clinic effects and prognosis of hyperoxygen compound sodium chloride solution (HCSCS) in treatment of burn shock. METHODS: (1) Severe burned patients with 50% - 69% TBSA were enrolled and randomly divided into 2 groups, treated by HCSCS and CSCS respectively. Indices such as PaO(2), Hb, Hct and complication were observed. (2) Severe burned patients with more than 70% TBSA were enrolled and indices above and lactate were investigated as well. RESULTS: (1) The cases treated with HCSCS showed relatively stabilization during shock stage, little complication, less liquor volume and remarkable higher oxygen pressure. (2) Severe burned patients with more than 70% TBSA had high level of PaO(2) and normal lactate and less complication. CONCLUSION: The early application of HCSCS is a relatively effective method in treatment of burn shock and favourable prognosis.
Keywords:Burns  Hyperoxygen compound sodium chloride solution (HCSCS)
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