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CD15nRNA,CD44v6mRNA及nm23H1mRNA在乳腺癌组织中的表达及 …
引用本文:Gu H,Ni C,Zhan R. CD15nRNA,CD44v6mRNA及nm23H1mRNA在乳腺癌组织中的表达及 …[J]. 中华医学杂志, 2000, 80(11): 854-857
作者姓名:Gu H  Ni C  Zhan R
作者单位:中国人民解放军第251医院,张家口
摘    要:目的 探讨CD15mRNA及其蛋白、CD44v6mRNA和nm23H1 mRNA在乳腺癌组织中的表达及与乳腺癌患者预后的关系。方法 应用催化信号放大(CSA)原 杂交和免疫组织化学方法,对94例乳腺癌患者的癌组织进行了CD15 mRNA及其蛋白、CD44v6 mRNA和nm23H1 mRNA低表达均与乳腺癌患者的组织学分级、临床分期、淋巴结转移、复发和预后密切相关。CD15 mRNA和CD44v6

关 键 词:乳腺癌 CD15 mRNA CD44 nm23H1 抗原 原位杂交
修稿时间:2000-04-26

The expression of CD15 mRNA CD44v6 mRNA and nm23H1 mRNA in breast cancer and their clinical significance
Gu H,Ni C,Zhan R. The expression of CD15 mRNA CD44v6 mRNA and nm23H1 mRNA in breast cancer and their clinical significance[J]. Zhonghua yi xue za zhi, 2000, 80(11): 854-857
Authors:Gu H  Ni C  Zhan R
Affiliation:Department of Pathology, Chinese PLA 251 Hospital, Zhangjiakou 075000, China.
Abstract:OBJECTIVE: To study the relationship of the expression of CD15 mRNA and its protein, CD44v6 mRNA and nm23H1 mRNA with the clinical pathology parameter and prognosis of breast cancer, and to investigate the correlation of the expression of CD15 mRNA with CD44v6 mRNA and nm23H1 mRNA. METHODS: Catalyzed signal amplification (CSA) method of in situ hybridization and immunohistochemistry were used to detect the expression of CD15 mRNA and its protein, CD44v6 mRNA and nm23H1 mRNA in 94 cases of breast cancer. RESULTS: The overexpression of CD15 mRNA and its protein and CD44v6 mRNA and the low expression nm23H1 mRNA were correlated with the grading, clinical stage, lymph node metastasis, recurrence and prognosis of breast cancer. Patients who had overexpression of CD15 mRNA and CD44v6 mRNA and low expression of nm23H1 mRNA had a higher lymph node metastatic rate and a lower survival rate. CONCLUSION: The expression of CD15 mRNA has a synergistic action in positive and negative regulation with that of CD44v6 mRNA and nm23H1 mRNA. Combining detection of the expression of these three mRNA is a reliable index to evaluate the metastasis, recurrence and prognosis of breast cancer.
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