| X连锁遗传的薄基底膜肾病与COL4A5基因连锁 |
| |
| 引用本文： | 张承英,朱世乐,章友康.X连锁遗传的薄基底膜肾病与COL4A5基因连锁[J].中华医学杂志,2000,80(8):582-584. |
| |
| 作者姓名： | 张承英 朱世乐 章友康 |
| |
| 作者单位： | [1]北京武警部队总医院肾内科 [2]北京医科大学第一临床医院肾内科 |
| |
| 基金项目： | 国家自然科学基金!资助项目 (39870 353) |
| |
| 摘 要： | 目的 运用Ｘ染色体上与ＣＯＬ４Ａ５基因紧密连锁的微卫星标志２Ｂ６及ＤＸＳ１０１对９个薄基底膜肾病家系进行基因连锁分析。方法 用ＰＣＲ扩增９例薄基底膜肾病患者及其家系成员Ｘ染色体上的微卫星标志２Ｂ６及ＤＸＳ１０１，１０％聚丙烯酰胺凝胶电泳后银染分析结果，运用ＰＰＡＰ软件计算Ｌｏｄ ｓｃｏｒｅ值。结果 ３个家系的薄基底膜肾病与Ｘ染色体上的ＣＯＬ４Ａ５基因连锁，座位间的Ｌｏｄ ｓｃｏｒｅ值为２．７，θ＝
|
| 关 键 词： | 薄基底膜肾病 X连锁遗传 COL4A5基因连锁 |
| 修稿时间： | 1999-07-28 |
X-linked thin basement membrane nephropathy was linked with COL4A5 gene |
| |
| ZHANG Chengying,ZHU Shile,ZHANG Youkang.X-linked thin basement membrane nephropathy was linked with COL4A5 gene[J].National Medical Journal of China,2000,80(8):582-584. |
| |
| Authors: | ZHANG Chengying ZHU Shile ZHANG Youkang |
| |
| Institution: | Department of Nephrology, The First Hospital of Beijing Medical University, Beijing 100034, China. |
| |
| Abstract: | OBJECTIVE: To genetically analyze 9 thin basement membrane nephropathy (TBMN) pedegrees using microsatellite marker 2B6 and DXS101 closely linked with COL4A5 gene located on chromosome X. METHODS: Genomic DNA was extracted. Highly polymorphic microsatellite markers (2B6 and DXS101) closely linked with COL4A5 gene located on chromosome X were amplified with PCR. Nine TBMN families were analysed. RESULTS: Three of 9 TBMN families were linked with COL4A5 gene on chromosome X (lod score = 2.7, theta = 0.00). CONCLUSION: X-linked TBMN is linked with COL4A5 gene on chromosome X. |
| |
| Keywords: | Kidney diseases Basilar membrane Linkage (Genetics) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
