甲型肝炎减毒活疫苗与灭活疫苗免疫效果的比较

目的 观察甲型肝炎（甲肝）减毒活疫苗Ｈ２株与ＬＡ－１株的不同剂量、不同免疫程序的免疫原性及抗体动脉变化。方法 在河北、广西两地５选择３１８名经甲肝抗体检测为阴性的易感儿童，按不同剂量程序及不同甲肝疫苗，分为６组，并在首剂接种后１、６、７、１２、１３月份分别采集血清标本，检测甲肝总抗体。结果 各组抗体水平均于再免疫后１个月达高峰，以后开始下降，再免半年后抗体水平仍明显高于初免抗体水平；灭活于再免疫后

Comparison of immunology effects between live attenuated hepatitis A vaccine and inactivated hepatitis A vaccine

Objective To study the immunology effects of live attenuated hepatitis A vaccine in different doses and schedules groups, and compare with inactivated hepatitis A vaccine(Havrix, Smithkline). Methods 318 susceptible children were enrolled in Guangxi and Hebei province. These subjects were divided into six groups. Each group was vaccinated with either inactivated vaccine or different doses and schedules of live attenuated vaccine. Serum specimens were collected and tested for anti HAV antibody at different time after the vaccination. Results GMT of each group arrived at the peak 1 months after re vaccination, then declined, and GMT of 6 months after booster dose was still significantly higher than that after primary immunization. Sero conversion rates in all groups reached 100% after a booster dose, and kept at 6 months after booster dose. Conclusions A booster dose of live attenuated vaccine can induce secondary immune response well. The immunology effects after booster dose are comparable with inactivated vaccine and it should be useful to the immune persistence.