实时动态血糖监测与静脉血糖、毛细血管血糖检测的相关性

目的 研究实时动态血糖监测系统(RT-CGMS)与静脉血糖、毛细血管血糖检测的相关性.方法 收集2009年8至12月在哈尔滨医科大学附属第二医院治疗的33例糖尿病患者佩戴5 dRT-CGMS,期间测定静脉和毛细血管血糖值.应用相关分析、Clarke误差表格分析、Bland-Altman分析比较RT-CGMS与静脉血糖及毛细血管血糖的相关性;计算患者佩戴RT-CGMS期间的平均血糖波动幅度(MAGE).结果 (1)RT-CGMS与静脉、毛细血管血糖值的相关系数分别为0.936和0.933(均P<0.01).(2)Clarke误差表格分析显示静脉组和毛细血管组分别有98.67%和98.64%的点位于A区(临床准确区)与B区(临床可接受区);没有点位于C区(数据误差区);分别有1.33%和1.36%的点位于D区(数据错误区).(3)Bland-Altman分析RT-CGMS与静脉血糖、毛细血管血糖值在(x)±1.96范围内.(4)MAGE相同的患者HbA1c差异较大.结论 RT-CCMS与静脉血糖、毛细血管血糖检测具有良好的相关性、准确性和一致性.

Correlation of real-time continuous monitoring system with venous glucose and capillary glucose values

Objective To study the correlation of real-time continuous monitoring system (RT-CGMS) with venous glucose and capillary glucose values. Methods A total of 33 diabetics received RT-CGMS for 5 days. Fasting venous glucose values were measured at Days 1, 3 and 5 and capillary glucose values recorded 7 times daily. The methods of correlation coefficient, error grid analysis(EGA) and BlandAltman analysis were employed to assessed the correlation, accuracy and agreement of RT-CGMS with venous glucose and capillary glucose values respectively. The mean amplitude of glucose excursions (MAGE) was calculated during RT-CGMS testing periods. Results (1) The correlation coefficient of RT-CGMS with vein glucose and capillary glucose values were 0. 936, 0. 933 (P < 0. 01); (2) The analysis results of EGA showed that 98. 67%, 98. 64% of venous and capillary values fell in the A and B zones and 1. 33%,1.36% fell in the D zone; (3) The agreement analysis showed that RT-CGMS readings were in close agreement with venous glucose and capillary glucose results; (4) The patients at the same M AGE levels had obvious differences in HbAlC. Conclusion There is a high level of correlation, accuracy and agreement between RT-CGMS and venous glucose and capillary glucose values.