中国成人不同糖代谢异常的分布特点

目的　探讨各种不同的糖代谢异常 (糖调节受损和糖尿病 )在中国人群中的分布和特点。方法　研究对象为 1994年全国糖尿病防治协作组资料库中具有完整口服糖耐量试验 (OGTT)资料的 15 6 37例中国成人 (≥ 2 5岁 )。参考 1999年WHO糖尿病诊断标准将研究对象分为 7组 :正常糖耐量 NGT ,空腹血糖 (FPG) <6 1mmol/L及OGTT2小时血糖 (PG 2h) <7 8mmol/L]、单纯空腹血糖受损 (i IFG ,6 1≤FPG <7 0mmol/L及PG 2h <7 8mmol/L)、单纯糖耐量异常 (i IGT ,FPG<6 1mmol/L及 7 8≤PG 2h <11 1mmol/L)、同时FPG及PG 2h异常 (IFG/IGT ,6 1≤FPG <7 0mmol/L及 7 8≤PG 2h <11 1mmol/L)、单纯空腹高血糖的糖尿病 (IFH ,FPG≥ 7 0mmol/L及PG 2h <11 1mmol/L)、单纯餐后高血糖的糖尿病 (IPH ,FPG <7 0mmol/L及PG 2h≥ 11 1mmol/L)、同时空腹及餐后高血糖的糖尿病 (IFH/IPH ,PG 2h≥ 11 1mmol/L及FPG≥ 7 0mmol/L)。计算以上各种糖代谢异常在本组人群发生频率并比较其临床特点。结果　 (1)NGT、i IFG、i IGT、IFG/IGT、IFH、IPH和IFH/IPH的频率分别为 5 0 8%、8 8%、12 3%、6 1%、6 4 %、5 2 %和 10 4 %。 (2 )i IGT、IFG/IGT、IPH和IFH/IPH的频率有随年龄而增加的趋势 ,但i IFG和IFH频率分别在 2 5～ 34岁和 5 5

The distributive characteristics of impaired glucose metabolism subcategories in Chinese adult population

OBJECTIVE: To clarify the frequencies and clinical features of different impaired glucose metabolism subcategories in Chinese adults. METHODS: A cross-sectional analysis of the data of 15,637 Chinese adults (aged >or= 25 years) who underwent standard 75 g oral glucose tolerance test from the National Diabetes Mellitus Survey (1994) was conducted. According to the 1999 WHO criteria for diabetes, the subjects were divided into 7 groups: normal glucose tolerance (NGT, FPG < 6.1 mmol/L and PG 2 h < 7.8 mmol/L), isolated impaired fasting glucose (i-IFG, 6.1 or= 7.0 mmol/L and PG 2 h < 11.1 mmol/L), isolated postload hyperglycemia (IPH, FPG < 7.0 mmol/L and PG 2 h >or= 11.1 mmol/L), and combined IFH and IPH (IFH/IPH, FPG >or= 7.0 mmol/L and PG 2 h >or= 11.1 mmol/L). The frequencies of the above subcategories were calculated and the clinical characteristics were compared. RESULTS: (1) The frequencies of NGT, i-IFG, i-IGT, IFG/IGT, IFG, IPH, and IFH/IPH were 50.8%, 8.8%, 12.3%, 6.1%, 6.4%, 5.2%, and 10.4% respectively. (2) The frequencies of i-IGT, IFG/IGT, IPH, and IFH/IPH increased with age, whereas the frequencies of i-IFG and IFH tended to plateau in the age groups of 25 - 34 years and 55 - 64 years. (3) The mean age and blood pressure were significantly lower in the i-IFG group (vs the i-IGT or IFG/IGT group) and the IFH group (vs IPH or IFH/IPH group). Compared with the IPH group, the IFH group had higher homeostasis model assessment (HOMA) insulin resistance index (HOMA-IR) and lower beta cell function index (BCI). CONCLUSIONS: i-IGT is the most common impaired glucose regulation (IGR) subcategory, and IFH/IPH is the most common diabetes subcategory in Chinese adults. The frequencies of i-IGT and IFH/IPH increase with age. The clinical features of i-IFG (IFG) are greatly different from those of i-IGT (IPH), suggesting that the determinants of FPG and PG 2 h differ.