早发冠心病与血管紧张素Ⅱ-1型受体A1166/C基因多态性的相关性研究

目的：研究血管紧张素Ⅱ－1型受体（AT1R）基因A1166／C多态性与中国早发冠心病（CHD）发生的相关关系及其对血脂水平的影响。方法：采用聚合酶链反应一限制性片段长度多态性（PCR－RFLP）分子生物学方法,检测71例早发CDH患者,76例迟发CHD患者和119例健康对照者的AT1R基因型;并按常规方法测定血脂水平。结果：共检测出2种AT1R基因型,分别是AA型和AC型,早发CHD组及迟发CHD组AA基因型（97．2％,92．1％）和AC基因型（2．8％,7．9％）频率与对照组（94．1％,5．9％）相比差异均无统计学意义。等位基因A和C频率在3组间差异无显著意义。AT1R基因多态性与血脂水平无关。结论：AT1R基因A1166／C多态性与早发CHD的发生发展似无直接关系。

Association between early-onset coronary heart disease and angiotensin II type 1 receptor gene polymorphism

Objective To study the association between early onset coronary heart disease (CHD) and angiotensin II type 1 receptor (ATIR) gene A1166/C polymorphism and the effect of ATIR gene A1166/C on the plasm lipid level. Methods The ATIR A1166/C genotype of 71 early onset CHD patients, 76 late onset CHD patients, and 119 controls was examined by PCR RFLP. Their plasma lipid levels were detected. Results Two ATIR genotypes, AC and AA, were detected. The frequencies (97.2% vs 92.1% vs 94.1%) of genotypes AA and AC and the frequencies of allele A and allele C in the three groups were similar. No difference were found among the levels of plasma lipids in the group of early onset CHD patients with AA (94.1% vs 5.9%) or AC genotypes (2.8% vs 7.9%). Conclusion There is no association berween between ATIR gene A1166/C polymorphism and occurrence of early onset CHD. ATIR geng A1166/C polymorphism has no effect on plasma lipid levels.