不同碘摄入量地区甲状腺癌的流行病学研究

目的 研究不同碘摄入量对≥14周岁人媲甲状腺癌发生的影响。方法 选择和肋山、彰武和黄骅3个农村社区分别为低碘、适碘和高碘地区。入户调查3个地区≥14周岁人数共22976人甲状腺癌发生情况，并采集当地部分居民空腹尿、饮用水和食用盐样口进行检测。结果 盘山、彰武和黄骅地区成人尿碘中位数分别为103、375和615μg/L。盘山、彰武均未发现甲状腺癌患者，黄骅则发现10例甲状腺乳头状癌。1994年以来，黄骅地区甲状腺癌患病率为91.58/10万，平均年发病率为13.12/10万。结论 高碘是区甲状腺癌发病率高于低碘的适碘地区。

Comparative epidemiological study on thyroid cancer in areas with different iodne intades

OBJECTIVE: To investigate the status of thyroid cancer among people aged 14 and over residing in areas with different iodine intakes. METHODS: In-door interviews on prevalence of thyroid cancer were conducted among 22 976 persons aged 14 and over residing in three rural communities in Panshan County, Liaoning Province, an iodine deficient area, Zhangwu County, Liaoning Province, an iodine sufficient area, and Huanghua County, Hebei Province, an iodine excessive area. Morning fasting urine, drinking water and table salt were collected from part of the interviewees to be tested. RESULTS: The medians of urinary iodide were 103.2 microgram/L, 374.8 microgram/L and 614.6 microgram/L among the interviewees in Panshan, Zhangwu and Huanghua respectively. No patient with thyroid cancer was found in Panshan and Zhangwu, while 10 interviewees in Huanghua were suffering from thyroid papillary carcinoma. During the period of 1994 - 2000, the prevalence of thyroid cancer was 91.58/100 000, and the incidence was 13.12/100 000 per year in Huanghua. CONCLUSION: The prevalence and incidence of thyroid cancer in iodine excessive area are much higher than those in the other two areas.