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前列腺癌穿刺与切除标本Gleason评分比较
作者姓名:Xia T  Dong J  Zhang J
作者单位:1. 100034,北京大学第一医院北京大学泌尿外科研究所
2. 北京市公安医院泌尿外科
摘    要:目的 比较胶列腺穿刺活检标本与根治性切除术标本的Gleason评分。方法 对 40例前列腺穿刺活检标本的Gleason评分及对应的根治性切除术标本的Gleason评分进行配对t检验。结果 穿刺活检组 2~ 9分 ,平均 (5 6± 1 7)分 ;根治性切除术组 4~ 10分 ,平均 (6 4± 1 3)分 ;两组差异显著 (P <0 0 5 )。结论 前列腺穿刺活检标本的Gleason评分低于根治性切除术标本的Gleason评分。宜采取相应措施降低低估率。

关 键 词:前列腺癌  Gleason评分  穿刺活检  根治性切除术

Gleason scores of prostate needle biopsy specimens and of radical prostatectomy specimens,a comparative study
Xia T,Dong J,Zhang J.Gleason scores of prostate needle biopsy specimens and of radical prostatectomy specimens,a comparative study[J].National Medical Journal of China,2002,82(23):1604-1605.
Authors:Xia Tongli  Dong Jiechang  Zhang Jun
Institution:Institute of Urology, Peking University, Beijing 100034, China.
Abstract:OBJECTIVE: To compare the Gleason scores of the prostate needle biopsy specimens with those of the radical prostatectomy specimens. METHODS: Gleason scoring was made on the needle biopsy specimens from 40 patients with prostate carcinoma and then on the radical prostatectomy specimens from the same patients. The Gleason scores of the two sets of matched specimens were compared. RESULTS: The Gleason scores were 2 approximately 9 (5.6 +/- 1.7) of the prostate needle biopsy specimens, significantly different from those of the radical prostatectomy specimens 4 approximately 10 (6.4 +/- 1.3), P < 0.05]. The Gleason scores coincided in 23 cases (57.5%) between the two groups. The Gleason scores of 15 needle biopsy specimens were significantly lower than those of the matched radical prostatectomy specimens with an underestimation rate of 37.5% and were higher in 2 needle biopsy specimens than in the matched radical prostatectomy specimens with an overestimation rate of 5.0%. The number of cases with the Gleason score < or = 6 in the needle biopsy group were 25, significantly less than that in the radical prostatectomy group (P < 0.01). The number of cases with the Gleason score > or = 7 in the needle biopsy group was 15, not significantly different from that in the prostatectomy group (P = 0.07). CONCLUSION: Prostate needle biopsy under-grades the Gleason scores in comparison with radical prostatectomy. Measures should be adopted to avoid underestimation of the tumor grade.
Keywords:Prostate carcinoma  Gleason scores  Needle biopsy  Radical prostatectomy
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