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颅内长形动脉瘤的三维数值模拟及血流动力学分析
引用本文:穆士卿,杨新健,张莹,罗斌,吕明,吴中学,李海云,王盛章,丁光宏.颅内长形动脉瘤的三维数值模拟及血流动力学分析[J].中华医学杂志,2009,89(5).
作者姓名:穆士卿  杨新健  张莹  罗斌  吕明  吴中学  李海云  王盛章  丁光宏
作者单位:1. 首都医科大学附属北京天坛医院,北京神经外科研究所,100050
2. 首都医科大学生物工程学院
3. 复旦大学力学和工程科学系
基金项目:国家自然科学基金,北京市自然科学基金,北京市优秀人才培养资助个人项目,首都医科大学基础临床合作课题 
摘    要:目的 应用计算流体力学软件对颅内长形动脉瘤进行三维数值模拟,以分析其血液动力学特性.方法 对象为10例长形动脉瘤,其中8例曾经有蛛网膜下腔出血史.联合应用Matlab软件、Ansys软件、Fluent软件及自写程序对其进行计算机数值模拟.结果 长形动脉瘤模型流入道的血流速度(1.07±0.23)m/s]、动压(574±186)Pa]及壁面切应力(7.7±2.0)Pa]最高,流出道次之,顶部血流速度(0.15±0.07)m/s]、动压(37±13)Pa]及肇而切应力(0.40±0.13)Pa]最低;瘤内不形成或仪形成简单涡流.结论 长形动脉瘤顶部是动脉瘤破裂的主要部位,可能与动脉瘤顶部血流速度、动压及壁面切应力均最低有关.搏动性血流对动脉瘤的发生、生长和破裂起有重要作用.

关 键 词:颅内动脉瘤  计算流体力学  三维数值模拟

Three-dimensional numerical simulation and hemodynamic analysis of intracranial longitypical aneurysms
MU Shi-qing,YANG Xin-jian,ZHANG Ying,LUO Bin,LU Ming,WU Zhong-xue,LI Hai-yun,WANG Sheng-zhang,DING Guang-hong.Three-dimensional numerical simulation and hemodynamic analysis of intracranial longitypical aneurysms[J].National Medical Journal of China,2009,89(5).
Authors:MU Shi-qing  YANG Xin-jian  ZHANG Ying  LUO Bin  LU Ming  WU Zhong-xue  LI Hai-yun  WANG Sheng-zhang  DING Guang-hong
Abstract:Objective To establish a model of three-dimensional numerical simulation of intracranial longitypical aneurism and analyze the hemodynamic features thereof. Methods Ten patients with intracranial longitypical aneurism underwent surgical treatment. Iutracranial vascular ultrasonography was conducted before operation. Intra-operatively three-dimensional angiography of the aneurysm was conducted and multifunctional physiological monitor was used to record the dynamic pressure and pressure wave form of the main branch parent artery. Matlab, Ansys, and Fluent softwares were used to simulate the blood flow of the longitypical aneurisms. Results The hemodynamic parameter levels were the highest at the inflow tract, followed by those at the outflow tract, and were the lowest at the top of aneurysm, for example, the blood flow velocity was (1.07 ±0.23) m/s, the dynamic pressure was (574±186) Pa, and the wall shear stress was (7.7±2.0) Pa at the inflow tract, all significantly higher than those at the top (0.15± 0.07) m/s, ( 37±13 ) Pa, and (0.40±0.13 ) Pa respectively, all P<0.05 ]. No eddy or just simple eddy occurred in the aneurysm. Conclusion The dynamic pressure, velocity, and wall shear stress are the lowest at the top of longitypical aneurysm which may contribute to the rupture of aneurysm.
Keywords:Intracranial aneurysm  Computational fluid dynamics  Numerical simulation
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