幽门螺杆菌感染者胃粘膜癌前病变与cmet 原癌基因蛋白表达的关系

目的研究幽门螺杆菌（Ｈｐ）感染后胃粘膜癌前病变中ｃ－ｍｅｔ原癌基因蛋白表达的情况,了解Ｈｐ在胃癌发生过程中的作用。方法１１０例经病理证实为慢性胃炎的病人用免疫组织化学方法检测胃粘膜细胞中ｃ－ｍｅｔ原癌基因蛋白表达。结果在浅表性胃炎、萎缩性胃炎、肠化生及异型增生中,ｃ－ｍｅｔ原癌基因蛋白的表达率分别为２２．２％、４４．１％、６７．５％、６１．９％。过量表达率分别为５．５％、２６．４％、３７．８％、３８．１％。Ｈｐ感染者ｃ－ｍｅｔ原癌基因蛋白表达率明显较未感染者高,分别为６３％及３２％。在萎缩、肠化生及异型增生等癌前病变中,Ｈｐ感染者与未感染者表达率分别为６８．９％及３０．５％（Ｐ＜０．０５）。结论随着病变的进展,ｃ－ｍｅｔ原癌基因的表达随之增加,Ｈｐ感染对ｃ－ｍｅｔ原癌基因蛋白表达有一定的影响。

The relationship between Helicobacter pylori and expression of c-met oncogene in gastric precancerous lesions

Objectives To determine whether there is a relationship between the presence of H. pylori and alteration of c met oncogene and to estimate the role of H.pylori in the development of gastric carcinoma. Methods 110 patients with histopathologically proven chronic gastritis were studied. We demonstrated expression and overexpression rates of c met oncogene by using immunohistochemical staining. Results For chronic superficial gastritis, chronic atrophic gastritis, intestinal mataplasia and dysplasia, the expression rates were 22.2%, 44.1%, 67.5% and 61.9%. The overexpression rates were 5.5%, 26.4%, 37.8% and 38.1% respectivly. The positive rates of c met oncogene protein were high among patients infected with H. pylori than those with no H.pylori infection (63% vs 32%). In the precancerous lesions of cellular atrophy, intestinal mataplasia and dysplasia, the expression rates of H. pylori positive patients were higher (68.9%) than those of H.pylori negative patients (30.5%) ( P <0.05). Conclusions H. pylori is involved in the expression of c met oncogene.