三亚地区翼状胬肉发病与紫外线暴露时间相关关系研究

目的 研究紫外线辐射与翼状胬肉发病的量效关系。方法 海南省三亚市崖城地区95例翼状胬肉患者作为翼状胬肉组，在当地人群中按相同年龄、性别、民族、是否戴眼镜和帽子的标准选取95名志愿者进行1：1配对，作为正常对照。将两组人群按年龄分为青年、中年、老年3个阶段，通过详细询问研究对象个体累积户外活动的时间，填写调查表，以此计算个体紫外线暴露时间，作为紫外线暴露量，进行比较分析两组的紫外线暴露时间与翼状胬肉发病的关系。结果 在青年组（35637h＋13587h or 26188h＋17423h；t=3．352，P=0．006，与中年组（73412h＋23082h or 63368h＋25091h；t=2．322，P=0．024）患有翼状胬肉人群紫外线暴露时间明显高于对照组，而在老年翼状胬肉组（106816h＋37423h or 106748h＋43111h）与对照组的紫外线暴露时间未见有统计学意义（t=0．008，P=0．994）；翼状胬肉的长度与紫外线暴露时间呈正相关（r=0．361，P〈0．05），且随年龄增长而其长度也增加。结论 紫外线辐射与翼状胬肉发病之间存在一定的量效关系。

Relationship between pterygium onset and ultraviolet rays exposure time

OBJECTIVE: To investigate the dose-effect relationship between the radiation of ultraviolet ray and the onset of pterygium quantitatively. METHODS: Interrogation was conducted to 95 patients with pterygium in Yacheng district, Sanya City, Hainan Province, 37 males and 58 females, aged 55.7 +/- 13.8 (20 - 80), and 95 local volunteers in 1:1 pairs matched in age, sex, race, and similar habits of wearing glasses and caps (control group). Both the pterygium group and control group were re-divided into three sub-groups: youth (aged < or = 40), middle-aged (aged 41 - 60), and elderly (aged > 60). The time of exposing to ultraviolet ray was calculated. Photo of the pterygium was taken. The length of the pterygium invading into cornea was measured. RESULTS: The ultraviolet ray exposure time of the youth subgroup, pterygium group, was 35,637 +/- 13,587 hours, significantly higher than that of the youth subgroup, control group (26,188 +/- 17,423 hours, t = 3.352, P = 0.006). The ultraviolet ray exposure time of the middle-aged subgroup, pterygium group, was 73,412 +/- 23,082 hours, significantly higher than that of the middle-aged subgroup, control group (63,368 +/- 25,091 hours, t = 2.322, P = 0.024). However, there was no significant difference in the ultraviolet ray exposure time between the elderly subgroups of both groups. The length of the pterygium invading into cornea was positively correlated with the ultraviolet ray exposure time (r = 0.361, P < 0.05), and the length showed a trend of increased with aging. CONCLUSION: There is a certain dose-effect correlation between ultraviolet ray exposure and the etiology of pterygium.