中国汉族人代谢综合征与脑卒中密切相关

目的 探讨中国汉族人代谢综合征与脑卒中的关系。方法 多中心病例对照研究。病例为1934例初发脑卒中患者，年龄在30～74岁间，对照为1839例年龄、性别和居住地匹配者。代谢综合征诊断按ATPⅢ定义和根据国人向心性肥胖的标准修改定义。结果 代谢综合征的现患率在各脑卒中病例组均高于对照组。ATPⅢ定义的代谢综合征的现患率在脑卒中病例组为28．2％，对照组为10．1％；腔梗、血栓性脑梗死和脑出血的代谢综合征现患率分别为30．9％、22．7％和29．4％。调整年龄、性别和其他脑卒中危险因素后，代谢综合征依然增加了脑卒中患病的危险，按ATPⅢ标准对上述3组不同类型脑卒中的OR值分别为4．04(3．22～5．08)、2．48(1．90～3．25)和3．67(2．7～4．3)。结论 国人中代谢综合征与脑卒中患病危险增加相关，这种关系独立于脑卒中的其他危险因素。

Metabolic syndrome strongly linked to stroke in Chinese

OBJECTIVE: To assess the association of the metabolic syndrome with stroke in Chinese using the definition of ATP III, and revised definition according to Chinese criteria for abdominal obesity. METHODS: Multi-center case control study, 1934 first-ever-stroke patients (Atherothrombosis, lacunar infarction, and intracerebral hemorrhage) aged 30 to 74 years were sequentially recruited. And 1839 age, gender and geographically matched subjects were included as controls. RESULTS: The prevalence of metabolic syndrome defined by either ATP III or Chinese criteria was significantly increasing in patients with lacunar infarction, cerebral atherosclerosis, or intracerebral hemorrhage than control subjects. After age- and sex-adjusted and further adjusted age, sex, total cholesterol, smoking, drinking, and education levels, the metabolic syndrome defined by ATP III criteria was associated with a 2.7 to 4.3 fold and 2.5 to 4.0 fold higher risk of the three stroke subtypes, respectively. CONCLUSION: the metabolic syndrome defined by ATP III and revised according to Chinese criteria of abdominal obesity was positively associated with the risk of stroke in our case control study. This study underscores the need for well-designed prospective study in Chinese to give further evidence to the link between metabolic syndrome and stroke.