| 川芎嗪逆转人胃癌耐药细胞SGC7901/ADM多药耐药的实验研究 |
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| 引用本文： | 曲正,侯培珍,曲伟,王颖慧.川芎嗪逆转人胃癌耐药细胞SGC7901/ADM多药耐药的实验研究[J].包头医学院学报,2005,21(3):220-221. |
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| 作者姓名： | 曲正 侯培珍 曲伟 王颖慧 |
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| 作者单位： | 包头医学院第一附属医院,内蒙古,包头,014010 |
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| 摘 要： | 目的:观察中药钙通道阻滞剂川芎嗪(TMP)对胃癌耐药细胞系SGC7901/ADM多药耐药(MDR)的逆转.方法:采用四唑氮蓝(MTT)法以川芎嗪为逆转剂,观察化疗药物对SGC7901/ADM的杀伤作用.结果:采用非细胞毒剂量的300mg/L TMP,能提高5-Fu的细胞杀伤作用.结论:TMP是一种有效的逆转胃癌MDR的中药逆转剂.
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| 关 键 词： | 胃肿瘤 川芎嗪 多药耐药 |
| 文章编号： | 1006-740X（2005）03-0220-02 |
| 收稿时间： | 2005-03-16 |
| 修稿时间： | 2005年3月16日 |
Reversal of Multidrug Resistance of SGC7901/ADM Gastric Carcinoma Cell Line by Tetramethylpyrazine |
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| Qu Zheng,HOU Peizhen,QU Wei,Wang Yinghui.Reversal of Multidrug Resistance of SGC7901/ADM Gastric Carcinoma Cell Line by Tetramethylpyrazine[J].Journal of Baotou Medical College,2005,21(3):220-221. |
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| Authors: | Qu Zheng HOU Peizhen QU Wei Wang Yinghui |
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| Abstract: | Objective:To investigate the reversal of multidrug resistance (MDR) of gastric carcinoma cell line SGC7901/ADM by traditional Chinese medicine tetramethylpyrazine(TMP).Methods:MTT assay was used to investigate the cytotoxicity of the drugs against human gastric carcinoma cell line SGC7901/ADM in vitro.Results:The cytotoxicity of 5-Fu to SGC7901/ADM was enhanced by TMP at nontoxic doses.Conclusion:TMP may be a safe and effective revertant to MDR. |
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| Keywords: | Gastric carcinoma Tetramethylpyrazine Muhidrug - resistant |
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