惠州市成人非酒精性脂肪性肝病流行病学调查与干预措施

目的：探讨非酒精性脂肪肝患者进行饮食及有氧运动等干预措施的临床疗效。方法：应用随机分层抽样的方法,对4个城乡居民区的成年人群进行体检及问卷调查,同时完善相关理化及腹部B超检查。选择非酒精性脂肪肝患者100例,随机分为对照组及实验组,实验组患者在硫普罗宁基础上予强化饮食及运动干预,对照组予硫普罗宁。结果：总共纳入2645名受访者,其中非酒精性脂肪肝患者378例,农村人群患病率低于城市,男性高于女性;随着年龄增长,非酒精性脂肪肝的患病率也逐渐增高,其中60-70岁间最高。治疗后,实验组患者的血脂及肝功水平改善优于对照组,且B超结果提示脂肪肝恢复到正常的人群比例也明显多于对照组（P〈0.05）。结论：我市成年人群中非酒精性脂肪肝的发病率较高,其危险因素为血脂异常及年龄。通过使用药物结合生活方式的干预,可以有效改善患者的肝功,降低血脂,提高临床的疗效。

Correlative Analysis of Epidemic Survey and Interventions for Nonalcoholic Fatty Liver Disease of Huizhou Adults

Objective： To explore the clinical effects of interventions on nonalcoholic fatty liver disease（ NAFLD） patients. Mehtod： Physical examination and questionnaire survey were performed in adults from 4urban and rural residential areas,adopted stratified random sampling method.100 cases of NAFLD patients were randomly divided into control group and experimental group,the experimental group was given strenthing diet and exercise interventions based on tiopronin,the control group was treated with tiopronin.Result： There were 2645 respondents,including 378 cases of NAFLD patients,and the NAFLD incidecne of rural was lower than the urban,the male was higher than the female. After treatment,the level improvement of blood lipids and liver function of experimental group was better than the control group,and the B ultrasonic result showed that the cases that fatty liver returned to normal of experimental group was significantly more than that in control group（ P〈0.05）.Conclusion： The NAFLD incidence of our city adults is high,the risk factors are dyslipidemia and age.By combining drugs with life style intervention can improve the liver function for patients,decrease the blood lipids and enhance the clinical efficacy.