老年急性髓细胞白血病患者院内感染分析

目的：总结老年急性髓细胞白血病患者院内感染及治疗情况，以期提高治疗水平。方法：回顾分析27例老年急性髓细胞白血病患者的院内感染发生率、感染部位、危险因素和治疗情况等，并与同期85例非老年患者进行比较。结果：老年组发生院内感染22例（81．5％），高于同期非老年组（56例，65．9％）。感染部位以呼吸系统多见（15例，68．2％）。危险因素为白细胞减少、化疗和合并症。单纯抗生素治疗有效率33．3％，抗生素加辅助治疗有效率61．1％，二者相比差异有显著性（P＜0．05）。治疗总有效率为68．2％。结论：老年急性髓细胞白血病患者院内感染发生率高于同期非老年组。抗生素加辅助治疗优于单纯抗生素治疗。控制感染与骨髓缓解有关。

Analysis of the hospital infection of elderly patients with acute myeloid leukemia

Objective: To improve the treatment of the hospital infection of the elderly patients with acute myeloid leukemia. Methods:The data of the hospital infection and treatment of 27 elderly acute leukemic patients were reviewed , including the inciden-ce of nosocomial infection, the most commonly infected site, the risk factors and the overall response rate. Results:The incidence of nosocomial infection was 81.5%. The most commonly infected site was respiratory system (68.2%). The factors of high risk included low WBC (86.4%), chemotherapy (81.8%) and complication (63.6%). The response rate with antibiotics alone and antibiotics combined with supportive therapy was 33.3% and 61.1% respectively (p<0.05). The overall response rate was 68.2%. Conclusions: The incidence of nosocominal infection of elderly acute leukemic patients was higher than non-elderly group in the same period. The combination of antibiotics with supportive therapy was better than antibiotics alone. Control of infection is related to acute leukemic remission.