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急性冠脉综合症诊断中检测心肌肌钙蛋白I肌红蛋白及肌酸激酶同工酶及超敏C-反应蛋白的意义
引用本文:王临光,王海波,付强,李先进.急性冠脉综合症诊断中检测心肌肌钙蛋白I肌红蛋白及肌酸激酶同工酶及超敏C-反应蛋白的意义[J].河北医学,2006,12(1):1-3.
作者姓名:王临光  王海波  付强  李先进
作者单位:1. 江苏省徐州市心血管病研究所,江苏,徐州,221009
2. 江苏省徐州市中心医院,江苏,徐州,221009
摘    要:目的:探讨实验室诊断在急性冠脉综合症早期诊断中的意义。方法:采用化学发光法测定68例冠心病(CHD)患者及40例正常对照组超敏C反应蛋白(hs-HS-CRP)、心肌肌钙蛋白I(cT-nI)、肌红蛋白(Mb)、肌酸激酶同工酶(CK-MB)的阳性率。结果:CHD组患者的hs-HS-CRP、cTnI、Mb、CK-MB的阳性率均明显高于正常对照组(P<0.05)。CHD组又分为3组,急性心机梗死组(AM I)20例、不稳定型心绞痛组(UA)28例、稳定型心绞痛组(SA)20例。AM I组患者的hs-HS-CRP、cTnI、CK-MB和Mb阳性率均明显高于SA组(P<0.01);UA组hs-CRP和cTnI阳性率均明显高于SA组(P<0.01),但两组间CK-MB和Mb阳性率相比无显著差异(P>0.05)。结论:冠心病发生与hs-HS-CRP和cTnI的增高相关。

关 键 词:超敏C反应蛋白  心肌肌钙蛋白I  肌酸激酶同工酶  肌红蛋白  冠心病
文章编号:1006-6233(2006)01-0001-03

Measurement of hs-C-Reactive Protein,Cardiac Troponin I,Creatine Kinase Isoenzyme MB and Myoglobin in the Diagnosis of Acute Coronary Syndrome
WANG Lin - guang , et al.Measurement of hs-C-Reactive Protein,Cardiac Troponin I,Creatine Kinase Isoenzyme MB and Myoglobin in the Diagnosis of Acute Coronary Syndrome[J].Hebei Medicine,2006,12(1):1-3.
Authors:WANG Lin - guang  
Institution:The angiocardiopathy Institute of Xuzhou , Jiangsu Xuzhou 221009, China
Abstract:Objective: To investigate the early diagnosis of acute coronary syndrome.Methods: By using immuneturbidity test and enzyme for rapid quantification,hsC-reactive protein(hs-HS-CRP),cardiac troponin I(cTnI),creatine kinase isoenzyme MB(CK-MB)and myoglobin(Mb) were measured in 68 patients with acute coronary syndrome(ACS group) and 40 healthy volunteers(control group).Results: The positive rate of hs-HS-CRP,cTnI,CK-MB and Mb in ACS group was significantly higher than those in control group(P<0.05).The patients with ACS were divided into 3 groups: 25cases of acute my cocardial infarction(AMI group),23 cases of unstable angina pectoris(UA group)and 20 cases of stable angina pectoris(SA group).The positivre rate of hs-HS-CRP,cTnI,CK-MB and Mb in the AMI group were significantly higher than those in the SA group(P<0.05),but there was no siginificant difference in the positive rate of of CK-MB and Mb between UA group and SA group.Conclusion: There was a significant correlation between the evalation of hs-HSCRP,cTnI and the risk of ACS events.
Keywords:Hs-C-reactive protein  Cardiac troponin I  Creatine kinase isoenzyme  Myoglobin  Acute coronary syndrome  
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