幽门螺杆菌的感染状态对胃癌患者预后临床研究

目的:探讨幽门螺杆菌的感染状态对于临床胃癌患者预后的一定影响作用.方法:收集本院50例确诊的胃癌组织标本,提取其DNA以PCR法检测标本中的幽门螺杆菌的感染状态,同时运用血清学方法检测患者血清中幽门螺杆菌IgG;以上病例标本按组织学类型、肿瘤组织大小、TNM分期、有无淋巴结转移及患者生存时间等临床病例数据与胃癌组织中幽门螺杆菌的感染情况进行分析.结果:50例胃癌组织中幽门螺杆菌感染率为62.0% (31/50);经分析不同组织学类型、胃癌组织分型中幽门螺杆菌的感染率差异各无统计学意义(P>0.05),而pTNM分期、病人生存时间和是否淋巴结转移中三项中发生幽门螺杆菌感染组与未感染组均有显著性差异(P<0.05).结论:幽门螺杆菌的感染状态可能对胃癌患者的预后有一定的影响作用.

Study on the Effect of Helicobacter Pylori Infection on Prognosis of Patients with Gastric Cancer

Objective: To investigate the effect of helicobacter pylori(Hp) infection on prognosis of patients with gastric cancer.Method: Tissue samples of fifty pathologically confirmed gastric cancer were collected,after their deoxyribonucleic acids(DNA) were extracted,the situation of Hp infection were determined by using polymerase chain reaction(PCR).Simultaneously,Hp immunoglobulin G(IgG) was detected by means of enzyme linked immunosorbent assay(ELISA).Afterwards,analysis was performed according to the clinical data such as tissue source,size of the tumor tissue,TNM stage,lymph node metastasis,survival time of the patients and the infection situation of Hp in gastric cancer tissue.Result: The infection rate of Hp in the gastric cancer tissue was 62.0%(31/50) in all 50 cases.After analysis in detail,the infection rate in gastric cancer tissue showed no statistical difference among different tissue source(P>0.05).Whereas,pTNM stage,survival time of the patients and lymph node metastasis were significantly different between Hp infection group and non-Hp infection group(P<0.05).Conclusion: Hp infection situation may affect the prognosis of patients with gastric cancer.