多发性硬化和视神经脊髓炎患者血清尿酸和同型半胱氨酸水平分析

目的:研究多发性硬化(multiple sclerosis,MS)、视神经脊髓炎(neuromyelitisoptica,NMO)患者以及健康人群血浆尿酸(uric acid,UA)水平和同型半胱氨酸(homocysteine,HCY)水平及其关系特点。方法:分别检测68例MS患者,96例NMO患者以及100名健康人群血浆UA和HCY水平,根据临床特征如年龄、性别、分型和残疾程度细分组别,并比较各组UA和HCY水平差异。结果:MS组和NMO组血浆UA水平较健康对照组更低,差异有统计学意义。MS组患者血浆HCY水平较NMO和健康对照组高,差异有统计学意义。多发性硬化组EDSS评分大于3.5组的HCY水平高于EDSS低于3.5组,差异有统计学意义。结论:血浆UA水平低和高HCY血症可能与多发性硬化的发病有关。HCY水平可能与多发性硬化患者残疾程度有关。低血浆尿酸水平可能与NMO发病相关。

Analysis of serum uric acid and homocysteine levels in pateints with multi-ple sclerosis and neuromyelitis optica

Objective:To investigate the serum uric acid( SUA) and homocysteine( HCY) levels in pateints with multiple sclero-sis,neuromyelitis optica and healthy people,and their relations among three groups. Methods:SUA and HCY levels were determined in 68 patients with MS,96 patients with NMO,as well as 100 healthy controls. UA and HCY levels were compared among groups according to the clinical characteristics such as age,sex,type and handicapped degree. Results:The SUA levels in patients with MS and NMO were significantly lower than those in the healthy control group. The HCY levels in patients with MS were significantly higher than those in the NMO group and healthy control group. In the MS group,the HCY levels in patients with EDSS score above 3. 5 were significantly higher than those in patients with EDSS score below 3. 5. Conclusion:Low SUA level and hyperhomocysteinemia may contribute to pathological mechanism of MS. The level of HCY may be associated with the severity of MS. Low SUA level may be correlated with the pathological mechanism of NMO.