参芪扶正注射液治疗晚期肺癌患者癌因性疲乏的临床疗效及生活质量评价

目的:观察参芪扶正注射液治疗晚期肺癌患者癌因性疲乏的临床疗效,并对患者的生活质量进行评价。方法:89例病理确诊为晚期肺癌患者随机分为对照组45例和治疗组44例。对照组给予单纯对症治疗,治疗组在对照组对症治疗的基础上静滴参芪扶正注射液,每日1次,连续应用3周为1个疗程。两组均治疗2个疗程。采用Piper疲乏量表(PFS)对两组患者治疗前后的疲乏程度进行比较;采用中医症状分级量化积分来比较两组患者治疗前后的疗效差异;采用Karnofsky行为状态评分表(KPS)、血红蛋白(Hb)水平及美国纽约心脏病学会(NYHA)的心脏功能分级对两组患者治疗前后的疗效进行评价;同时比较两组患者的中医证候疗效差异,并对两组患者治疗后的生活质量进行评价。结果:治疗组治疗后的疲乏总分、行为疲乏、情感疲乏、感知疲乏及认知疲乏的评分均显著低于对照组治疗后(P<0.05);治疗组治疗后的各中医症状的分级量化积分均显著低于对照组治疗后(P<0.05);治疗组治疗后的KPS评分,Hb值及心功能分级结果与对照组相比有显著差异(P<0.05);治疗组的总有效率要显著好于对照组(56.82%vs.83.72%),两者差异有统计学意义(χ2=7.512,P=0.006<0.05);且治疗组治疗后的躯体功能、角色功能、认知功能、情绪功能、社会功能以及总生活质量评分均显著高于对照组治疗后(P<0.05)。结论:参芪扶正注射液能够降低晚期肺癌患者的癌因性疲乏程度,改善中医证候,提高KPS评分、Hb水平及心功能分级,并明显改善患者的生活质量。

Clinical efficacy and quality of life evaluation of Shenqi Fuzheng Injection in the treatment of cancer related fatigue in patients with advanced lung cancer

Objective:To observe the clinical effect of Shenqi Fuzheng Injection (SQFZI) in the treatment of cancer-related fatigue (CRF) in patients with advanced lung cancer,and to evaluate the quality of life of the patients.Methods:89 cases of advanced lung cancer were randomly divided into control group (n=45) and treatment group (n=44).The control group was given symptomatic treatment,the treatment group in the control group on the basis of symptomatic treatment of intravenous infusion of SQFZI,once a day,continuous treatment for 3 weeks for a course of treatment.Two groups were treated for 2 courses.The PFS fatigue degree of the patients between two groups before and after treatment were compared,the Chinese medicine symptom classification of quantitative score between two groups before and after treatment were compared;using Karnofsky Behavior Scale (KPS),hemoglobin (Hb) and the New York society of Cardiology (NYHA) was conducted to evaluate the efficacy of cardiac function classification in two groups before and after treatment,the TCM syndrome curative effect were compared between two groups,and to evaluate quality of life in two groups of patients after treatment.Results:The total score of fatigue behavior,fatigue,emotional fatigue,perceived fatigue and cognitive fatigue scores of treatment group were significantly lower than the control group after treatment (P<0.05).The quantitative grading integral of TCM symptoms of treatment group were significantly lower than the control group after treatment (P<0.05);the scores of KPS,Hb and cardiac function were significantly different between the treatment group and the control group after treatment (P<0.05).The total efficiency of the treatment group was significantly better than the control group (56.82% vs.83.72%),the difference was statistically significant (χ2=7.512,P=0.006<0.05).The physical function,role function,cognitive function,emotional function,social function and quality of life scores were significantly higher than the control group after treatment (P<0.05).Conclusion:SQFZI can reduce the degree of cancer-related fatigue in patients with advanced lung cancer,improve TCM syndrome,improve KPS score,Hb value and cardiac function classification,and significantly improve the quality of life of patients.