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| 雷公藤粘胶分散型贴剂质量标准研究 | |
| 引用本文： | 许可为,陈丽华,朱若凯,蔡佳,管咏梅.雷公藤粘胶分散型贴剂质量标准研究[J].江西中医学院学报,2014,26(5):57-59. |
| 作者姓名： | 许可为 陈丽华 朱若凯 蔡佳 管咏梅 |
| 作者单位： | 1. 江西中医药大学附属医院药剂科 江西南昌330006 2. 江西省医药采购服务中心 江西南昌330029 3. 江西中医药大学现代中药制剂教育部重点实验室 江西南昌330004 |
| 基金项目： | 江西省卫生厅中医药科研计划 |
| 摘 要： | 目的：建立雷公藤粘胶分散型贴剂的质量标准。方法：采用薄层色谱（TLC）法对贴剂中有效成分雷公藤甲素进行鉴别;采用高效液相色谱法对雷公藤甲素进行含量测定。结果：TLC斑点清晰,分离度较好;雷公藤甲素浓度在0.5~10μg/mL范围内与峰面积积分值呈良好线性关系,r=0.9999（n=7）,平均加样回收率为100.97%,RSD=1.64%（n=9）。结论：所建标准可用于雷公藤粘胶分散型贴剂的质量控制。 |
| 关 键 词： | 雷公藤 粘胶分散型贴剂 质量标准 薄层色谱法 高效液相色谱法 |
Study on Quality Standard of Tripterygium Wilfordii Drug-in-adhesive Patch |
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| XU Ke-wei,CHEN Li-hua,ZHU Ruo-kai,CAI Jia,GUAN Yong-mei.Study on Quality Standard of Tripterygium Wilfordii Drug-in-adhesive Patch[J].Journal of Jiangxi College of Traditional Chinese Medicine,2014,26(5):57-59. | |
| Authors: | XU Ke-wei CHEN Li-hua ZHU Ruo-kai CAI Jia GUAN Yong-mei |
| Institution: | XU Ke - wei, CHEN Li - hua, ZHU Ruo - kai , CAI Jia, GUAN Yong - mei( 1. Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China ; 2. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China; 3. Medicine procurement service center of Jiangxi province, Nanchang 330029, China.) |
| Abstract: | Objective： To establish the quality standard for Tripterygium wilfordii drug- in- adhesive patch. Methods： Triptolide, which acted as the main effective component of the patch, was identified by TLC and its content in the patch was determined by HPLC. Results ： The TLC spots were clear and well - separated. The linear range of triptolide in the patch was 0.5 - 10μg/mL （ r = 0. 9999, n = 7 ） with the average recovery of 100.91% （ RSD = 1.40% , n = 9 ）. Conclusion ： The method is feasible for the quality control of Tripterygium wilfordii drug - in - adhesive patch. |
| Keywords: | Tripterygium wilfordii Drug - in - adhesive patch Quality Standard TLC HPLC |
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