天合保肾合剂对大鼠糖尿病肾病肾脏保护作用的研究

目的：探讨天合保肾合剂对糖尿病肾病（DN）大鼠的肾脏保护作用。方法：单肾切除及链尿佐菌素（STZ）尾静脉注射诱导DN模型;设正常组,模型组,卡托普利组,天合保肾合剂高、中、低剂量组;8 w后测定DN大鼠空腹血糖（GLU）、糖化血红蛋白（GHb）、尿素氮（BUN）、血肌酐（Scr）,光镜观察肾脏病理组织学变化。结果：天合保肾合剂能够降低DN大鼠血糖、糖化血红蛋白（GHb）、尿素氮（BUN）、血肌酐（Scr）含量,与模型对照组比较有显著性差异（P〈0.01）,肾脏病理改变较模型组有明显减轻。结论：天合保肾合剂可以降低糖尿病肾病大鼠血糖,抑制糖化血红蛋白生成,改善肾功能,减轻肾脏病理变化,对DN大鼠具有肾脏保护作用。

The Effect of THBS Decoction on Renal Protective Function of Experimental Diabetic Nephropathy Rats

Objective:The effect of THBS Decoction on renal function of experimental diabetic nephropathy(DN) rats.Methods:The DN animal model was made by resection of one kidney and injection of strcptozotociri(STZ).DN rats were divided randomly into normal control group,DN control group,positive control group(captopril),experimental group(THBS Decoction).Blood sugar(GLU),Glycosylated Hemoglobin(GHb),Blood Urea Nitrogen(BUN) and serum creatinine(SCr)were observed at the end of 8 week.The changes of renal tissue morphology in experimental diabetic rats were observed by optical microscope.Results:The results showed THBS Decoction had a certain effect on reducing GLU and GHb as well as decreasing the experimental DN rats higher BUN,SCr,which had a significant statistic sense in comparing with DN control group(P<0.01).Besides it could ameliorate pathologic change in experimental DN rats obviously.Conclusion:The results indicated that THBS Decoction could reduce GLU and GHB,improve renal funition,ameliorate pathologic change in experimental DN rats,safeguard the diabetic kidney.