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葛根总黄酮对大鼠慢性肝损伤的保护作用
引用本文:喻松仁,程绍民,周步高,高书亮,邹富有.葛根总黄酮对大鼠慢性肝损伤的保护作用[J].江西中医学院学报,2010,22(1):70-72.
作者姓名:喻松仁  程绍民  周步高  高书亮  邹富有
作者单位:江西中医学院,南昌,330004
摘    要:目的:探讨葛根总黄酮对四氯化碳(CCl4)所致大鼠慢性肝损伤的保护作用,同时进一步探讨葛根总黄酮抗肝损伤可能的作用机制。方法:用CCl4制备慢性肝损伤动物模型。测定血清中天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)、透明质酸(HA)含量,并观察肝组织形态学变化。结果:葛根总黄酮能显著降低CCl4所致大鼠血清AST、ALT和HA含量的升高(p〈0.01);减轻对肝细胞的病理性损害。结论:葛根总黄酮对CCl4所致的大鼠慢性肝损伤具有一定的保护作用,其机制可能与清除氧自由基、抗脂质过氧化和抗纤维化有关。

关 键 词:葛根总黄酮  慢性肝损伤  保护作用

Protective Effects of Radices Puerarire Total Flavone against rats Chronic Liver Injury
YU Song-ren,CHENG Shao-min,ZHOU Bu-gao,GAO Shu-liang,ZOU Fu-you.Protective Effects of Radices Puerarire Total Flavone against rats Chronic Liver Injury[J].Journal of Jiangxi College of Traditional Chinese Medicine,2010,22(1):70-72.
Authors:YU Song-ren  CHENG Shao-min  ZHOU Bu-gao  GAO Shu-liang  ZOU Fu-you
Institution:YU Song-ren,CHENG Shao-min,ZHOU Bu-gao,GAO Shu-liang,ZOU Fu-you Jiangxi University of Traditional Chinese Medicine,Nanchang 330004
Abstract:Objective:To observe the protective effects of Radices Puerarire Total Flavone on carbon tetrachloride(CCl4) induced chronic hepatic injury of rats,and to explore its Possible mechanisms.Methods:chronic hepatic injury model was induced by CCl4.then the activities of aspartate transaminase(AST),alanine transaminase(ALT) and hyaluronic acid(HA) in blood serum were detected.Meanwhile the pathology of the liver was observed with microscopy.Results:Radices Puerarire Total Flavone significantly decrease the eleva...
Keywords:Radices Puerarire Total Flavone  Liver injury  Protective effect  
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