市售不同生产厂家牛黄解毒片黄芩苷的溶出度考察

目的：采用紫外分光光度法考察市售3个不同生产厂家牛黄解毒片的有效成分黄芩苷溶出度情况,评价药品质量差异。方法：以人工胃液为溶出介质,按药典溶出度转蓝法测定进行操作,以黄芩苷成分为评价指标,选用紫外分光光度法进行测定,绘制牛黄解毒片中黄芩苷成分的累积溶出曲线,并运用Excel软件进行数据处理,提取参数并进行相关性检验。结果：3个不同生产厂家牛黄解毒片黄芩苷溶出参数有极显著性差异。结论：市售牛黄解毒片药品黄芩苷溶出度处在明显的差异。

Commercially Available Tablets of Different Manufacturers Niuhuangjiedu Baicalin Dissolution

Objective：To examine commercially available UV spectrophotometry three different manufacturers of the active ingredient in Niuhuangjiedu tablets dissolution of baicalin and evaluate differences in drμg quality.Methods： The artificial gastric juice as a dissolution medium,according to Pharmacopoeia dissolution to blue determination to operate in order to evaluate the components of baicalin indicators,chosen by UV spectrophotometry,mapping Niuhuangjiedu Baicalin Cumulative dissolution profiles of components and using Excel software for data processing,extraction parameters and the associated test.Results： The three different manufacturers Niuhuangjiedu baicalin tablets dissolution parameters are very significant differences.Conclusion： The commercially available tablets drμgs Niuhuangjiedu baicalin significant difference in dissolution rate.