CT guided 125iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma |
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作者单位: | ZHANG Fu-jun,LI Chuan-xing,JIAO De-chao,WU Pei-hong,DUAN Guang-feng,WU Yue-xia(State Key Laboratory of Oncology in South China,Department of Imaging and Interventional Radiology,Cancer Centre,Sun Yat-sen University,Guangzhou,Guangdong 510060,China);ZHANG Nian-hua(Department of Oncology, Guangdong Second Provincial Traditional Chinese Medicine Hospital,Guangzhou,Guangdong 510095,China) |
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基金项目: | Guangdong Science Committee,No. 2006B35802009;Department of Technology and Science of Guangzhou,No. 2007Z3-E0251; |
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摘 要: | Background This study evaluated the clinical application of CT guided ^125iodine implantation in patients with portal vein tumor thrombus in primary hepatocellular carcinoma. Methods The ten patients (9 males and 1 female, aged from 36 to 72 years) with portal vein tumor thrombus accompanying hepatocellular carcinoma had been treated with comprehensive therapy including surgery, transcatheter arterial chemoembolization, radiotherapy ablation, microwave ablation or percutaneous ethanol injection. The average diameter of each tumor thrombus was 21.5 mm × 30.5 mm. Seeds of 30 MBq ^125I were implanted 5 mm apart within the portal vein tumor thrombus. The follow-up after 4 months included enhanced spiral CT. Results CT screening of the tumours indicated that 4 out of 10 patients showed complete response to the therapy, 5 partial response and 1 stable disease. Adverse effects included aggravated abdominal dropsy and temporarily increased transaminase, which were controlled by medical management. Severe complications such as haemorrhage, biliary fistula hepatic abscess, pancreatic fistula and hepatic function failure were not observed. Implanted seeds migrated to lung and left hepatic lobe in 1 case. Conclusion CT guided implantation of ^125iodine seeds, can effectively treat portal vein tumor thrombus accompanying hepatocellular carcinoma with minimal damage and few complications.
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关 键 词: | ^125I 碘酒 经脉肿瘤血栓 短程治疗 早期肝细胞癌 |
CT guided 125iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma |
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Authors: | ZHANG Fu-jun LI Chuan-xing JIAO De-chao ZHANG Nian-hua WU Pei-hong DUAN Guang-feng WU Yue-xia |
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Institution: | ZHANG Fu-jun;LI Chuan-xing;JIAO De-chao;ZHANG Nian-hua;WU Pei-hong;DUAN Guang-feng;WU Yue-xia |
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Abstract: | Background This study evaluated the clinical application of CT guided 125iodine implantation in patients with portal vein tumor thrombus in primary hepatocellular carcinoma.Methods The ten patients (9 males and 1 female,aged from 36 to 72 years) with portal vein tumor thrombus accompanying hepatocellular carcinoma had been treated with comprehensive therapy including surgery,transcatheter arterial chemoembolization,radiotherapy ablation,microwave ablation or percutaneous ethanol injection.The average diameter of each tumor thrombus was 21.5 mm×30.5 mm.Seeds of 30 MBq 125I were implanted 5 mm apart within the portal vein tumor thrombus.The follow-up after 4 months included enhanced spiral CT.Results CT screening of the tumours indicated that 4 out of 10 patients showed complete response to the therapy,5 partial response and 1 stable disease.Adverse effects included aggravated abdominal dropsy and temporarily increased transaminase,which were controlled by medical management.Severe complications such as haemorrhage,biliary fistula,hepatic abscess,pancreatic fistula and hepatic function failure were not observed.Implanted seeds migrated to lung and left hepatic lobe in 1 case.Conclusion CT guided implantation of 125iodine seeds,can effectively treat portal vein tumor thrombus accompanying hepatocellular carcinoma with minimal damage and few complications. |
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Keywords: | 125I iodine seed implantation portal vein tumor thrombus brachytherapy primary hepatocellular carcinoma |
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