| Evidence of apoptotic smooth muscle cells in proliferative intima of injured arteries |
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| 作者姓名： | 黄峻 尹航 冷静 姚玉宇 姚蓉芬 彭韬 李晶阁 |
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| 作者单位： | HUANG Jun 黄 峻，YIN Hang 尹 航，LENG Jing 冷 静，YAO Yuyu 姚玉宇，YAO Rongfen 姚蓉芬，PENG Tao 彭 韬 and LI Jingge 李晶阁 |
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| 基金项目： | Research Grant of National Ministry of Health,96- 1- 344; |
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| 摘 要： | Objective To investigate the occurrence and extent of apoptosis in the course of restenosis. Methods The experimental models of vessel narrowness and intima thickness were established in minipigs’ iliac arteries by balloon injury and specimens were retrieved on the 1st, 3rd, 6th,12th and 30th days for dynamic observation. Apoptotic smooth muscle cells (SMCs) were detected by terminal deoxynucleotidyl transferase- mediated dUTP nick- end labeling (TUNEL). Results Apoptotic SMCs occurred only in the thickened intima 12 days after injury accompanied with the proliferative SMCs, the percentage of apoptosis was 1. 94%±0. 42% on the 12th day and 1. 36%±0. 31% on the 30th day respectively. The low frequency of apoptosis compared with the proliferative SMCs was a feature in the restenotic pathology. Conclusions Apoptosis participates in the pathogenetic process of intimal thickening and its level was low compared with proliferation. The findings suggest that attempts to modulate apoptosis after vessel injury constitute a theoretical approach to the prevention of restenosis.
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| 关 键 词： | apoptosis · smooth muscle cells · proliferation · restenosis |
Evidence of apoptotic smooth muscle cells in proliferative intima of injured arteries |
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| HUANG Jun,YIN Hang,LENG Jing.Evidence of apoptotic smooth muscle cells in proliferative intima of injured arteries[J].Chinese Medical Journal,2000,113(1):10-13. |
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| Authors: | HUANG Jun YIN Hang LENG Jing |
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| Institution: | Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Pathology, Nanjing Medical University, Nanjing 210029, China;Department of Pathology, Nanjing Medical University, Nanjing 210029, China;Department of Pathology, Nanjing Medical University, Nanjing 210029, China;Department of Pathology, Nanjing Medical University, Nanjing 210029, China;Department of Pathology, Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | OBJECTIVE: To investigate the occurrence and extent of apoptosis in the course of restenosis. METHODS: The experimental models of vessel narrowness and intima thickness were established in minipigs' iliac arteries by balloon injury and specimens were retrieved on the 1st, 3rd, 6th, 12th and 30th days for dynamic observation. Apoptotic smooth muscle cells (SMCs) were detected by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). RESULTS: Apoptotic SMCs occurred only in the thickened intima 12 days after injury accompanied with the proliferative SMCs, the percentage of apoptosis was 1.94% +/- 0.42% on the 12th day and 1.36% +/- 0.31% on the 30th day respectively. The low frequency of apoptosis compared with the proliferative SMCs was a feature in the restenotic pathology. CONCLUSIONS: Apoptosis participates in the pathogenetic process of intimal thickening and its level was low compared with proliferation. The findings suggest that attempts to modulate apoptosis after vessel injury constitute a theoretical approach to the prevention of restenosis. |
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| Keywords: | apoptosis smooth muscle cells proliferation restenosis |
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