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Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China
作者姓名:Zhou M  Huang SG  Wan HY  Li B  Deng WW  Li M
作者单位:Department of Pulmonary MedicineRuijin Hospital,Shanghai Second Medical University,Shanghai 200025,China,Department of Pulmonary MedicineRuijin Hospital,Shanghai Second Medical University,Shanghai 200025,China,Department of Pulmonary MedicineRuijin Hospital,Shanghai Second Medical University,Shanghai 200025,China,Department of Nuclear MedicineRuijin Hospital,Shanghai Second Medical University,Shanghai 200025,China,Department of Pulmonary MedicineRuijin Hospital,Shanghai Second Medical University,Shanghai 200025,China,Department of Pulmonary MedicineRuijin Hospital,Shanghai Second Medical University,Shanghai 200025,China
基金项目:ThisstudywassupportedbytheScienceandTechnologyFoundationofTenthFive YearPlanofChina (No 2 0 0 1BA70 3B0 3 )
摘    要:Theincidenceofchronicobstructivepulmonarydisease(COPD)isincreasingnowandithasbecomeamajorpublichealthproblem ,especiallyforthosesmokers AlthoughthemechanismofCOPDisuncertain ,itisknownthatsmokingisthemajorcausalfactorofCOPD .However,only 1 0 %-2 0 %ofchronicheavycigarettesmokershaveairwayobstructionandrespiratorysymptoms,1 whichshowsthatCOPDisacomplexdiseaseinfluencedbygeneticfactors ,environment,andgenotype environmentinteractions 2  GeneticfactorsofCOPDindicatethatdifferentgenotyp…

关 键 词:遗传多态性  金属蛋白酶-9  易感性  慢性阻碍性肺部疾病  中国  西部地区  MMP-9

Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China
Zhou M,Huang SG,Wan HY,Li B,Deng WW,Li M.Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China[J].Chinese Medical Journal,2004,117(10):1481-1484.
Authors:Zhou Min  Huang Shao-guang  Wan Huan-ying  Li Biao  Deng Wei-wu  Li Min
Institution:1. Department of Pulmonary Medicine,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China
2. Department of Nuclear Medicine,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China
Abstract:Background There are many candidate genes for chronic obstructive pulmonary disease (COPD). Matrix metalloproteinase-9 (MMP-9) plays an essential role in tissue remodeling and repair associated with development of COPD. In this study we investigated the correlation between MMP-9 gene polymorphism and COPD susceptibility in the Han population of South China.Methods We examined the frequency of polymorphic genotypes of the MMP-9 promoter (-1562C/T) in 100 COPD patients and 98 healthy smokers by restriction fragment length polymorphism.Results The frequencies of polymorphic genotypes in promoters of MMP-9 were C/C 86%, C/T 14% in COPD group; and C/C 98%, C/T 2% in the control group. There were significant differences between the two groups (P<0.01). The allele frequencies were also significantly different between the COPD group and the control group (C allele frequency: 93% vs 99%, T allele frequency: 7% vs 1%, P<0.05 respectively).Conclusion The genetic polymorphism in promoters of MMP-9 gene is associated with the susceptibility to COPD in the Han population of South China.
Keywords:pulmonary disease  chronic obstructive  matrix metalloproteinase-9  genetic polymorphism
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