| Abstract: | Chromosome changes are studied in 21 cases
of chronic benzene poisoning, both hypodiploid
and hyperdiploid celLs are significantly increased.
Among the hypodiploid cells, deletion of Group
C,E and G chromosomes is observed. Analysis
of hyperdiploid cells reveals extra Group C' and
E chromosomes. The chromatid gaps and breaks
are mostly found in poisoned cases, but frag-
ments and minutes are less common. The
chromosome abnormalities induced by chronic
benzene intoxication may be considered further
proof of benzene metabolite acting chiefly
through changes in the nucleic acid metabolism. |
