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Basaloid squamous cell carcinoma of the esophagus: an immunohistochemical study of 8 cases
Authors:Huang ZZ  Shen YQ  Liang YR  Wu XY
Institution:Department of Pathology, Shantou University Medical College, Shantou 515031, China;Department of Pathology, Shantou University Medical College, Shantou 515031, China;Department of Pathology, Shantou University Medical College, Shantou 515031, China;Department of Pathology, Shantou University Medical College, Shantou 515031, China
Abstract:OBJECTIVE: To explore the biological features of basaloid squamous cell carcinoma (BSC) of the esophagus. METHODS: Cytokeratins (CK4, CK18 and CK19), epithelial membrane antigen (EMA), carcino embryo antigen (CEA), alpha-smooth muscle antigen (alpha-SMA), S-100, laminin (LN), collagen IV (Col-IV), neural-specific enolase (NSE), proliferating cell nuclear antigen (PCNA) and p53 antibodies were used to detect the corresponding antigen expression in 8 cases of BSC with ABC immunohistochemical methods. RESULTS: Two kinds of BSC cell components have different responses to the above antibodies. For basaloid cells (BCs), 7 cases were positive for CK19, and were negative for the other 4 epithelial antibodies CK4, CK18, CEA and EMA. BCs of 4 cases were positive to the muscular antibodies alpha-SMA and S-100, and the hyaline degeneration in the tumor nests was positive for LN and Col-IV. BCs had a high index of PCNA, with an average level of 54%. For squamous cells (SCs), 7 cases were positive for the epithelial antigen CK4, CEA and EMA, but were negative for CK19, alpha-SMA and S-100. The index of PCNA of SC was low, with an average level of 25%. CONCLUSION: BSC of the esophagus is a high-malignancy tumor which is of multi-oriented differentiation. BCs represent basal cells which have the tendency of myoepithelial differentiation and have strong proliferation ability, whereas SCs represent typical squamous cell differentiation.
Keywords:esophagus tumor  basaloid squamous carcinoma  immunohistochemistry
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