| Vitamin D receptor gene polymorphism and bone mineral density in patients with type 2 diabetes mellitus |
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| 作者姓名： | 马秀萍 景雅莉 秦伟 柴晓峰 许建萍 周铤 杨建国 |
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| 作者单位： | 北京邮电总医院内分泌科,北京,100032 |
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| 摘 要： | Objective To explore the relationship between vitamin D receptor (VDR) gene polymorphisms and bone mineral density (BMD) in patients with type 2 diabetes mellitus (DM) an d to better understand the pathogenesis of osteoporosis. Methods Ninety seven patients with type 2 DM were recruited for this study. BMD was mea sured by single photon absorptiometry at the lower one third of the nondominant radius and ulna. Polymorphisms of the VDR gene were analyzed by DNA amplificati on with polymerase chain reaction (PCR) and endonuclease digestion with Bsm Ⅰ. Results The respective frequencies of VDR genotypes were BB 18. 6%, Bb 27. 8% and bb 53 . 6%. The Z scores of the three groups were -1. 57±-0. 60, -1. 45±-0. 67 and -1. 41±-0. 81, respectively. Although the BMD of the Bb genotype DM patients was higher than that of BB genotype DM patients and lower than that of bb genoty pe DM patients, there were no significant differences. Conclusion These findings suggest a small influence of VDR gene polymorphism on the BMD of patients with type 2 DM. Further study on the value of VDR genotypes in the pat hogenesis of osteoporosis in diabetes mellitus is still needed.
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| 关 键 词： | 骨质疏松 维生素D受体 骨密度 糖尿病 |
Vitamin D receptor gene polymorphism and bone mineral density in patients with type 2 diabetes mellitus |
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| Ma Xiuping,JING Yali,QIN Wei,CHAI Xiaofeng,XU Jianping,ZHOU Ting,YANG Jianguo.Vitamin D receptor gene polymorphism and bone mineral density in patients with type 2 diabetes mellitus[J].Chinese Medical Journal,2001,114(11):1213-1215. |
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| Authors: | Ma Xiuping JING Yali QIN Wei CHAI Xiaofeng XU Jianping ZHOU Ting YANG Jianguo |
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| Institution: | Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China;Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China;Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China;Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China;Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China;Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China;Department of Endocrinology, Post and Telecommunications General Hospital, Beiji ng 100032, China |
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| Abstract: | OBJECTIVE: To explore the relationship between vitamin D receptor (VDR) gene polymorphisms and bone mineral density (BMD) in patients with type 2 diabetes mellitus (DM) and to better understand the pathogenesis of osteoporosis. METHODS: Ninety seven patients with type 2 DM were recruited for this study. BMD was measured by single photon absorptiometry at the lower one third of the nondominant radius and ulna. Polymorphisms of the VDR gene were analyzed by DNA amplification with polymerase chain reaction (PCR) and endonuclease digestion with Bsm I. RESULTS: The respective frequencies of VDR genotypes were BB 18.6%, Bb 27.8% and bb 53.6%. The Z scores of the three groups were -1.57 +/- -0.60, -1.45 +/- -0.67 and -1.41 +/- -0.81, respectively. Although the BMD of the Bb genotype DM patients was higher than that of BB genotype DM patients and lower than that of bb genotype DM patients, there were no significant differences. CONCLUSION: These findings suggest a small influence of VDR gene polymorphism on the BMD of patients with type 2 DM. Further study on the value of VDR genotypes in the pathogenesis of osteoporosis in diabetes mellitus is still needed. |
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| Keywords: | osteoporosis vitamin D receptor bone mi neral density diabetes mellitus |
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