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RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection
Authors:Duan Zhong-ping  Zhao Xiu-ying  Huang De-zhuang  He Li-xiang  Chen Yu  Zhao Chun-hui  Zheng Bo-jian
Institution:1. Beijing You-An Hospital, Capital University of Medical Science, Beijing 100054, China
2. Department of Microbiology, The University of Hong Kong, Hong Kong, China
Abstract:BACKGROUND: Regulated on activation, normal T-cell expressed and secreted (RANTES) plays a critical role in T-lymphocyte activation and proliferation. The process is involved in both acute and chronic phases of inflammation. The present study was to ascertain the possible correlations between chronic hepatitis B virus (HBV) infection and the RANTES gene polymorphisms and their expression. METHODS: The study included 130 HBV negative healthy donors and 152 patients with chronic hepatitis B (CHB) virus infection. The polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) were used to detect RANTES gene single nucleotide polymorphisms (SNPs). RANTES levels in the platelet depleted plasma were detected by enzyme linked immunosorbent assay (ELISA). RESULTS: RANTES alleles -403G, -28C and In1.1T were the predominant alleles in the subjects studied. No significant correlation was found between CHB infection and the RANTES alleles, while a significant correlation was found between CHB infection and increased RANTES expression in platelet depleted plasma (P < 0.05). CONCLUSIONS: SNPs in RANTES gene do not affect chronic HBV infection or the outcome of interferon-alpha treatment in patients positive for HBV "e" antigen (HBeAg+). However, patients with CHB infection express the higher levels of plasma RANTES, which is thus associated with CHB infection.
Keywords:RANTES gene  polymorphism  hepatitis B virus  infection
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