| Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats |
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| 作者姓名： | 周建中 雷寒 陈运贞 李法绮 马长生 |
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| 作者单位： | Department of Internal Medicine, The First Affiliated Hospital, Chongqing Univer sity of Medical Sciences, Chongqing 400016, China;Department of Internal Medicine, The First Affiliated Hospital, Chongqing Univer sity of Medical Sciences, Chongqing 400016, China;Department of Internal Medicine, The First Affiliated Hospital, Chongqing Univer sity of Medical Sciences, Chongqing 400016, China;Department of Internal Medicine, The First Affiliated Hospital, Chongqing Univer sity of Medical Sciences, Chongqing 400016, China;Department of Cardiology, Sino-Japan Friendship Hospital, Beijing 100029，China |
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| 摘 要： | ＰｒｏｔｅｉｎｋｉｎａｓｅＣ (ＰＫＣ )ｉｓａｎｉｍｐｏｒｔａｎｔｌｉｎｋｆａｃｔｏｒｉｎｐａｓｓｉｎｇｍｅｓｓａｇｅｓ ,1 ａｎｄＳｃｕｔｅｌｌａｒｅｉｎｈａｓｂｅｅｎｓｈｏｗｎｔｏｂｅａｋｉｎｄｏｆＰＫＣｉｎｈｉｂｉｔｏｒ 2 ＷｅｈｙｐｏｔｈｅｓｉｚｅｄｔｈａｔＳｃｕｔｅｌｌａｒｅｉｎｗｏｕｌｄｈａｖｅｓｏｍｅｅｆｆｅｃｔｏｎｔｈｅｐａｔｈｏｌｏｇｉｃｃｈａｎｇｅｓｉｎｔｈｅｈｅａｒｔｃａｕｓｅｄｂｙｈｙｐｅｒｔｅｎｓｉｏｎ Ｔｏｔｅｓｔｔｈｉｓｈｙｐｏｔｈｅｓｉｓ ,ｗｅｓｔｕｄｉｅｄ 10 ｍｏ…
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| 关 键 词： | spontaneously · hypertensive rat · ventricu lar remodeling · Scutellarein · collagen |
Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats |
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| ZHOU Jianzhong,LEI Han,CHEN Yunzhen,LI Faqi,MA Changsheng.Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats[J].Chinese Medical Journal,2002,115(3):375-377. |
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| Authors: | ZHOU Jianzhong LEI Han CHEN Yunzhen LI Faqi MA Changsheng |
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| Abstract: | Objective To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs).Methods Twelve SHRs were randomly divided into two groups.Scutellarein and saline (10 mg·kg-1·d-1()) were given by intraperitoneal injection to two gr oups of rats separately.Systolic blood pressure (SBP) and ventricular weight i ndex (LVW/BW, RVW/BW) were measured.A polarization microscope and an image ana lyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen.Results The pathologic changes in the left ventricle in the Scutellarein group rats (SHR D) improved to varying degrees, including hypertrophy of the cardiac muscle a nd collagen volume fraction.Conclusion Scutellarein can reverse ventricular remodeling, improve myocardial stiffness an d protect heart cardiac muscle. |
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| Keywords: | spontaneously hypertensive rat ventricula r remodeling Scutellarein collagen |
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