| Treatment of osteoporosis in men using dehydroepiandrosterone sulfate |
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| 作者姓名： | 孙宜萍 毛敏伟 孙丽华 冯缨缨 杨建芬 沈佩华 |
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| 作者单位： | Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai 20023 3, China;Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai 20023 3, China;Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai 20023 3, China;Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai 20023 3, China;Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai 20023 3, China;Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai 20023 3, China |
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| 基金项目： | ThisprojectwasgrantedbyShanghaiScienceCommittee (No 96 41190 2 4) |
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| 摘 要： | Objective To study the effect of dehydroepiandrosterone sulfate (DHEAS) treatment of osteo porosis in men with TBMD≥2.5SD.Methods Eighty- six patients were randomly divided into two groups: treatment group (n= 44) and control group (n=42). DHEAS (100 mg q.d.) was given to the treatment group for 6 months. Bone mineral density, (BMD), biochemical markers of bone absorption and formation and other serum biochemical markers were measured before and after DHEAS treatment. Drug side effects were also evaluated. Results After oral administration of DHEAS (100 mg q.d.) for 6 months, the serum concen trations of DHEAS and IGF- Ⅰ in the treatment group were 93.75%±16.1% and 1 7.71%±4.2% higher respectively than those in the control group (P<0.01) . The BMD of L(2), L(3), L(4), L(2)- 4 and Neck sections increased in the treatment group by 2.65%±0.65%, 2.70%±0.48%, 3.10%±0.41%, 2.82%±0.37% and 2.32%±0 .31%, respectively, as compared with that the control group (P<0.05 or 0. 01). No significant changes were observed in serum FT, E(2) and PSA concentrati ons in the treatment group as compared with the control group.Conclusion The treatment of osteoporosis in men with DHEAS is safe and effective.
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| 关 键 词： | dehydroepiandrosterone · dehydroepiandrosteron e sulfate · osteoporosis |
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate |
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| SUN Yiping,MAO Minwei,SUN Lihua,FENG Yingying,YANG Jianfen,SHEN Peihua.Treatment of osteoporosis in men using dehydroepiandrosterone sulfate[J].Chinese Medical Journal,2002,115(3):402-404. |
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| Authors: | SUN Yiping MAO Minwei SUN Lihua FENG Yingying YANG Jianfen SHEN Peihua |
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| Abstract: | |
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| Keywords: | dehydroepiandrosterone dehydroepiandrosterone sulfate osteoporosis |
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