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Clinical implications of increased expression of CD40L in patients with acute coronary syndromes
Authors:YAN Jinchuan  WU Zonggui  HUANG Zuo  LI Li  ZHONG Renqian  KONG Xiantao
Institution:Department of Cardiology, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China;Department of Cardiology, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China;Department of Cardiology, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China;Central Laboratory, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China;Central Laboratory, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China;Central Laboratory, Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China
Abstract:Objective To investigate clinical implications of expression of CD40L in monocytes and cha nges in serum soluble CD40L in patients with acute coronary syndromes (ACS). Methods Sixteen control and 56 patients, including 24 with stable angina (SA), 20 with u nstable angina (UA) and 12 with acute myocardial infarction (AMI) enrolled in th is study. Expression of CD40L in monocytes was analyzed by flow cytometry and s CD40L levels were measured by ELISA. Results Expression of CD40L in monocytes and serum levels of sCD40L in UA and AMI patien ts were higher than in SA patients and controls. In patients with AMI, sCD40L l evels showed no significant increase when compared to patients with UA, while AM I patients had a peak level of sCD40L at 24 hours after AMI. PTCA induced a mar ked rise in sCD40L levels in all patients, while CD40L expression in monocytes s howed no difference between patients with PTCA, before and after.Conclusion Enhanced level of serum sCD40L may be a reliable prognostic indicator for ACS an d may represent a marker of coronary disease activity.
Keywords:CD40 ligand  acute coronary syndromes  atherosclerosis
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