| Beneficial effects of NTG on left ventricular volumes and systolic function in patients with myocardial infarction. |
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| 作者姓名： | 杨跃进 陈在嘉 徐义枢 高润霖 寇文熔 杨浣宜 王燕武 |
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| 作者单位： | Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing，Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing，Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing，Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing，Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing，Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing，Cardiovascular Institute and Fu Wai Hospital，Chinese Academy of Medical Sciences，Beijing |
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| 摘 要： | The effect of sublingual administration and intravenous drip of nitroglycerin (SLNTG and IVNTG) on left ventricular volumes (LVVs) were studied and systolic function was quantitatively assessed with two-dimensional echocardiography (2DE) in 28 patients with myocardial infarction (MI), including 13 cases without heart failure (MI-NHF) in one group and 15 with heart failure (MI-HF) in another. The results showed that after SLNTG and IVNTG in both groups the heart rate (HR) increased significantly (P< 0.05-0.001); the systolic blood pressure (SBP) decreased significantly (P< 0.05-0.001); the diastolic blood pressure (DBP) was not significantly changed (all P>0.05); the left ventricular end-diastolic and end-systolic volumes (EDV and ESV) both significantly reduced EDV: decreased by 5.8-11.6% (-13.2-19.0 ml), P< 0.05-0.001; ESV: decreased by 9.6-16.6% (-8.6-17.3 ml), P< 0.05-0.001)1; the left ventricular ejection fraction (LVEF) all significantly elevated (increased by 6.6%-9.4% (3.2%-3.4%), P < 0.05-0.001
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