可吸收绷带治疗严重肝脏爆冲伤的对照研究：小型猪实验

Background  The aim of this research was to evaluate the feasibility and efficacy of absorbable bandage wrapping in the treatment of cases of severe liver trauma.

Methods  Electric firecrackers were detonated in 16 miniature swine to produce a severe blast liver injury. After fluid resuscitation, the animals were randomly divided into two groups (n=8 each) and were either treated with absorbable bandage wrapping of the injured lobe of liver (Group B) or hepatic lobectomy (Group H). Time to hemostasis, blood loss during the treatment period, and other parameters were compared, including postoperative serum total bilirubin (TB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST).

Results  Blood loss during the treatment period was significantly lower in Group B than that in Group H ((81.3±26.0) ml vs. (130.8±29.5) ml, P=0.0031). Serum AST and ALT were transiently increased post-surgically. These transient increases were significantly higher in Group B. No difference in time to hemostasis was noted ((8.70±2.27) minutes vs. (10.28±1.93) minutes, P=0.1559) in Groups B and H, respectively. Two pigs were humanely euthanized 28 days post-surgically and the wrapped liver lobes appeared atrophies. Microscopically, there was evidence of emerging and mature fibrous tissue.

Conclusion  Absorbable bandage wrapping is both feasible and effective in the treatment of severe blast liver injury.

Absorbable Bandage Wrapping in Treatment of Severe Blast Liver Injury: A Miniature Swine Model

Background The aim of this research was to evaluate the feasibility and efficacy of absorbable bandage wrapping in the treatment of cases of severe liver trauma.Methods Electric firecrackers were detonated in 16 miniature swine to produce a severe blast liver injury.After fluid resuscitation,the animals were randomly divided into two groups (n＝8 each) and were either treated with absorbable bandage wrapping of the injured lobe of liver (Group B) or hepatic lobectomy (Group H).Time to hemostasis,blood loss during the treatment period,and other parameters were compared,including postoperative serum total bilirubin (TB),alanine aminotransferase (ALT),and aspartate aminotransferase (AST).Results Blood loss during the treatment period was significantly lower in Group B than that in Group H ((81.3±26.0) ml vs.(130.8±29.5) ml,P＝0.0031).Serum AST and ALT were transiently increased post-surgically.These transient increases were significantly higher in Group B.No difference in time to hemostasis was noted ((8.70+2.27) minutes vs.(10.28±1.93)minutes,P＝0.1559) in Groups B and H,respectively.Two pigs were humanely euthanized 28 days post-surgically and the wrapped liver lobes appeared atrophies.Microscopically,there was evidence of emerging and mature fibrous tissue.Conclusion Absorbable bandage wrapping is both feasible and effective in the treatment of severe blast liver injury.