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| Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion | |
| 作者姓名： | Shi E Jiang X Bai H Gu T Chang Y Wang J |
| 作者单位： | Department of Cardiac Surgery，the First Affiliated Hospital，China Medical University，Shenyang 110001，China，Department of Anesthesiology，the First Affiliated Hospital，China Medical University，Shenyang 110001，China，Department of Infectious Disease the Second Affiliated Hospital，China Medical University，Shenyang 110004，China，Department of Cardiac Surgery，the First Affiliated Hospital，China Medical University，Shenyang 110001，China，Department of Anesthesiology，the Second Xiangya Hospital，Central South University，Changsha 410011，China，Department of Anesthesiology，the First Affiliated Hospital，China Medical University，Shenyang 110001，China |
| 摘 要： | Objective To investigate the cardioprotective effects of morphine on ischemic reperfused rat heart in vitro and its mechanism.Methods The isolated rat heart was perfused in a Langendorff apparatus. Infarct myocardium was determined by TTC. Coronary flow (CF), heart rate (HR), left ventricular pressure (LVP), the first derivative of ventricular pressure (LVP/dtmax) and infarct size after ischemia and reperfusion in rat heart given 0.3 μmol/L morphine were observed. The effects of naloxone and glibenclamide on the cardioprotection of morphine were also measured.Results After ischemia and reperfusion, CF, HR, LVP and LVP/dtmax of isolated rat hearts decreased significantly (P<0.01). After morphine preconditioning, HR, LVP and LVP/dtmax increased (P<0.01) and infarct size was reduced significantly (P<0.01), while no significant change in CF (P>0.05). The cardioprotective effects of morphine were abolished by naloxone or glibenclamide completely.Conclusions Morphine can reduce ischemia-reperfusion injuries in isolated rat heart. The cardioprotective effects of morphine are mediated by a local opioid receptor-KATP channel linked mechanism in rat hearts. |
| 关 键 词： | 心功能 阿片受体 缺血再灌注 动物模型 钾离子通道 吗啡 作用机制 |
Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion |
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| Shi E,Jiang X,Bai H,Gu T,Chang Y,Wang J.Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion[J].Chinese Medical Journal,2003,116(7):1059-1062. | |
| Authors: | Shi Enyi Jiang Xiaojing Bai Han Gu Tianxiang Chang Yetian Wang Junke |
| Institution: | 1. Department of Cardiac Surgery , the First Affiliated Hospital, China Medical University, Shenyang 110001, China 2. Department of Anesthesiology, the First Affiliated Hospital, China Medical University, Shenyang 110001, China 3. Department of Infectious Disease, the Second Affiliated Hospital, China Medical University, Shenyang 110004, China 4. Department of Anesthesiology , the Second Xiangya Hospital, Central South University, Changsha 410011, China |
| Abstract: | OBJECTIVE: To investigate the cardioprotective effects of morphine on ischemic reperfused rat heart in vitro and its mechanism. METHODS: The isolated rat heart was perfused in a Langendorff apparatus. Infarct myocardium was determined by TTC. Coronary flow (CF), heart rate (HR), left ventricular pressure (LVP), the first derivative of ventricular pressure (LVP/dtmax) and infarct size after ischemia and reperfusion in rat heart given 0.3 micro mol/L morphine were observed. The effects of naloxone and glibenclamide on the cardioprotection of morphine were also measured. RESULTS: After ischemia and reperfusion, CF, HR, LVP and LVP/dtmax of isolated rat hearts decreased significantly (P < 0.01). After morphine preconditioning, HR, LVP and LVP/dtmax increased (P < 0.01) and infarct size was reduced significantly (P < 0.01), while no significant change in CF (P > 0.05). The cardioprotective effects of morphine were abolished by naloxone or glibenclamide completely. CONCLUSIONS: Morphine can reduce ischemia-reperfusion injuries in isolated rat heart. The cardioprotective effects of morphine are mediated by a local opioid receptor-K(ATP) channel linked mechanism in rat hearts. |
| Keywords: | morphine ischemia and reperfusion opioid receptor |
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